2-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclohex-2-enone | 1228931-87-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclohex-2-enone
• 英文别名: 2-(1-Hydroxy-3-phenylprop-2-ynyl)cyclohex-2-en-1-one；2-(1-hydroxy-3-phenylprop-2-ynyl)cyclohex-2-en-1-one
• CAS: 1228931-87-0
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: MFFUSBJXFPECGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclohex-2-enone 、 乙酸酐 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以80%的产率得到2-(1-acetoxy-3-phenylprop-2-yn-1-yl)cyclohex-2-enone
  参考文献：
  名称：

  3,5-Disubstituted 6H-pyrrolo[1,2-c][1,2,3]triazoles from Morita–Baylis–Hillman adducts of propargyl aldehydes

  摘要：

  A simple method for synthesizing several 6H-pyrrolo[1,2-c][1,2,3]triazole derivatives having a methoxy carbonyl or an acetyl group at C-5 position and 7,8-dihydro-4H-[1,2,3]triazolo[1,5-a]indol-5(6H)-ones via an intramolecular 1,3-dipolar cycloaddition reaction of azido enynes, which were readily obtained from the Morita-Baylis-Hillman acetates of propargyl aldehydes with sodium azide, has been developed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.03.017
• 作为产物：
  描述：

  苯丙炔醛 、 2-环己烯-1-酮 在 4-二甲氨基吡啶 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以40%的产率得到2-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclohex-2-enone
  参考文献：
  名称：

  3,5-Disubstituted 6H-pyrrolo[1,2-c][1,2,3]triazoles from Morita–Baylis–Hillman adducts of propargyl aldehydes

  摘要：

  A simple method for synthesizing several 6H-pyrrolo[1,2-c][1,2,3]triazole derivatives having a methoxy carbonyl or an acetyl group at C-5 position and 7,8-dihydro-4H-[1,2,3]triazolo[1,5-a]indol-5(6H)-ones via an intramolecular 1,3-dipolar cycloaddition reaction of azido enynes, which were readily obtained from the Morita-Baylis-Hillman acetates of propargyl aldehydes with sodium azide, has been developed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.03.017

文献信息

• 3,5-Disubstituted 6H-pyrrolo[1,2-c][1,2,3]triazoles from Morita–Baylis–Hillman adducts of propargyl aldehydes
  作者：Sun Pil Park、Sang-Hyun Ahn、Kee-Jung Lee

  DOI：10.1016/j.tet.2010.03.017

  日期：2010.5

  A simple method for synthesizing several 6H-pyrrolo[1,2-c][1,2,3]triazole derivatives having a methoxy carbonyl or an acetyl group at C-5 position and 7,8-dihydro-4H-[1,2,3]triazolo[1,5-a]indol-5(6H)-ones via an intramolecular 1,3-dipolar cycloaddition reaction of azido enynes, which were readily obtained from the Morita-Baylis-Hillman acetates of propargyl aldehydes with sodium azide, has been developed. (C) 2010 Elsevier Ltd. All rights reserved.