甲基2-D-吡喃葡萄糖苷 | 2140-41-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲基2-D-吡喃葡萄糖苷
• 英文名称: 2-O-Methylglucose
• 英文别名: 2-O-methyl-D-glucose；2-O-Methyl-D-glucopyranose；(3R,4S,5S,6R)-6-(hydroxymethyl)-3-methoxyoxane-2,4,5-triol
• CAS: 2140-41-2
• 化学式: C₇H₁₄O₆
• 分子量: 194.185
• InChiKey: UMPNFVHHMOSNAC-WLDMJGECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  甲基2-D-吡喃葡萄糖苷 在 盐酸 、 对甲苯磺酸 作用下， 以 乙腈 为溶剂， 生成 4,6-O-benzylidene-1,2-di-O-methyl-α-D-glucopyranoside
  参考文献：
  名称：

  Rao, A. V. Rama; Dhar, T. G. Murali; Gujar, M. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 999 - 1000

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3,4,6-tetra-O-acetyl glucopyranose 生成 甲基2-D-吡喃葡萄糖苷
  参考文献：
  名称：

  Koizumi, Kyoko; Utamura, Toshiko, Chemical and pharmaceutical bulletin, 1981, vol. 29, # 10, p. 2776 - 2784

  摘要：

  DOI：

文献信息

• Glycosyl Bunte Salts: A Class of Intermediates for Sugar Chemistry
  作者：Yasuhiro Meguro、Masato Noguchi、Gefei Li、Shin-ichiro Shoda

  DOI：10.1021/acs.orglett.7b03400

  日期：2018.1.5

  thiosulfates have been discovered as a new class of synthetic intermediates in sugar chemistry, named “glycosyl Bunte salts” after 19th-century German chemist, Hans Bunte. The synthesis was achieved by direct condensation of unprotected sugars and sodium thiosulfate using a formamidine-type dehydrating agent in water–acetonitrile mixed solvent. The application of glycosyl Bunte salts is demonstrated with transformation

  S-糖基硫代硫酸盐已被发现是糖化学中的一类新型合成中间体，以19世纪德国化学家汉斯·邦特（Hans Bunte）的名字命名为“糖基邦特盐”。通过在水-乙腈混合溶剂中使用甲am型脱水剂将未保护的糖和硫代硫酸钠直接缩合来完成合成。通过向其他糖基化合物如1-硫糖，糖基二硫化物，1，6-脱水糖和O-糖苷的转化反应证明了糖基邦特盐的应用。
• Distribution of methyl substituents over branched and linear regions in methylated starches
  作者：Yuri E.M. van der Burgt、Jack Bergsma、Ido P. Bleeker、Paul J.H.C. Mijland、Anca van der Kerk-van Hoof、Johannis P. Kamerling、Johannes F.G. Vliegenthart

  DOI：10.1016/s0008-6215(98)00238-9

  日期：1998.11

  Abstract Granular potato starch and amylopectin potato starch were methylated in aqueous suspension to molar substitutions (MS) up to 0.29. A method was developed to determine the MS of both branched and linear regions. After exhaustive digestion of the methylated starches with α -amylase, the highly branched fraction with a degree of polymerisation (DP) > 8 was separated from the linear oligomers

  摘要在水悬浮液中将颗粒马铃薯淀粉和支链淀粉马铃薯淀粉甲基化，使其摩尔取代度（MS）最高达到0.29。开发了一种方法来确定支链和线性区域的MS。用α-淀粉酶彻底消化甲基化淀粉后，通过将前者在甲醇中进行选择性沉淀，将聚合度（DP）> 8的高度支化级分与线性低聚物分离。确定支链和线性区域的取代水平。已发现甲基化优选发生在支链淀粉的分支区域，并且直链淀粉的取代度高于支链淀粉的线性区域。通过FABMS测定三聚体和四聚体中甲基取代基的分布，并将其与统计随机分布的结果进行比较。结果提供了异构取代基分布的证据。分支和线性区域的异质性程度的定量显示与线性区域中随机分布的偏差大得多。
• 5-FLUORO-C-(ARYL OR HETEROCYCLYL)-GLYCOSIDE DERIVATIVES USEFUL AS DUAL SGLT1 / SGLT2 MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20190055226A1

  公开（公告）日：2019-02-21

  The present invention is directed to 5-fluoro-C-(aryl or hetercyclyl)-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.

  本发明涉及5-氟-C-(芳基或杂环基)-糖苷衍生物，含有它们的药物组合物以及它们在治疗由SGLT活性调节的疾病和症状中的应用，更具体地说是双重SGLT1/2活性。
• [EN] 5,5-DIFLUORO- AND 5-FLUORO-5-METHYL-C-GLYCOSIDE DERIVATIVES USEFUL AS DUAL SGLT1 / SGLT2 MODULATORS<br/>[FR] DÉRIVÉS DE 5,5-DIFLUORO-ET 5-FLUORO-5-MÉTHYL-C-GLYCOSIDE UTILES EN TANT QUE MODULATEURS DUGLT1/SGLT2
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2019215633A1

  公开（公告）日：2019-11-14

  The present invention is directed to 5,5-difluoro- and 5-fluoro-5-methyl-C-glycoside derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by SGLT activity, more particularly dual SGLT1/2 activity.

  本发明涉及5,5-二氟-和5-氟-5-甲基-C-糖苷衍生物，含有它们的药物组合物以及它们在治疗由SGLT活性调节的疾病和症状中的应用，更具体地说是双重SGLT1/2活性。
• Methods And Systems For Growing Plants Using Silicate-Based Substrates, Cultivation Of Enhanced Photosynthetic Productivity And Photosafening By Utilization Of Exogenous Glycopyranosides For Endogenous Glycopyranosyl-Protein Derivatives, And Formulations, Processes And Systems For The Same
  申请人：Innovation Hammer, LLC

  公开号：US20140331555A1

  公开（公告）日：2014-11-13

  Methods for promoting plant growth based on novel photosafening treatment regimes with glycopyranosides including glycopyranosylglycopyranosides, and aryl-a-D-glycopyranosides, and more specifically, with one or more compounds comprising terminal mannosyl-triose, optionally in the presence of light enhanced by one or more light reflecting and/or refracting members such as silicon-based substrates. Furthermore, chemical synthesis processes for the above compounds are disclosed for general application to plants. Silicate microbeads of the like are distributed over the ground or substrate in which roots of a plant are supported and planted, beneath and around a plant in a manner that light is refracted or reflected toward the phylloplane.

  基于新型光保护处理方案促进植物生长的方法，包括甘露聚糖苷类化合物，如甘露聚糖苷和芳基-a-D-甘露聚糖苷，更具体地，使用含有端基甘露三糖的一个或多个化合物，可选地在存在硅基基底等一个或多个反射和/或折射光的成员的情况下增强光线。此外，还公开了上述化合物的化学合成过程，以供普遍应用于植物。类似的硅酸盐微珠分布在植物的根部支撑和种植的地面或基质上，在植物的下方和周围，使光线以折射或反射的方式朝向叶面。