hederagenin 3-O-α-L-arabinofuranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside | 84607-60-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: hederagenin 3-O-α-L-arabinofuranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside
• 英文别名: saponin C；(4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-3-[(2S,3R,4R,5S,6S)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 84607-60-3
• 化学式: C₄₆H₇₄O₁₆
• 分子量: 883.084
• InChiKey: XCTJSYZFNWZAES-UXDKCJHBSA-N

物化性质

• 沸点：
  987.3±65.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  62
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  255
• 氢给体数：
  9
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  hederagenin 3-O-α-L-arabinofuranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 在 中性纤维素酶 McIlvaine buffer 作用下， 生成 Alpha-常春藤苷
  参考文献：
  名称：

  Kimata, Hiroko; Nakashima, Taeko; Kokubin, Setsuko, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 6, p. 1998 - 2005

  摘要：

  DOI：
• 作为产物：
  描述：

  hederagenin 3-O-(3-O-acetyl-α-L-arabinofuranosyl)-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside 在 甲醇 、 sodium methylate 作用下， 反应 3.0h， 以73.3%的产率得到hederagenin 3-O-α-L-arabinofuranosyl-(1->3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranoside
  参考文献：
  名称：

  Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak

  摘要：

  研究发现，无患子（Sapindus rarak DC.）果皮的甲醇提取物及其皂苷部分（甲醇洗脱部分）可抑制橄榄油处理小鼠血浆甘油三酯的升高。从活性组分中分离出了三种新的酰化齐墩果烷型三萜皂甙，即无患子皂甙 IV（1）、V（2）和 VI（3）。根据化学和光谱证据，阐明了 1-3 的结构。主要的皂苷成分为赤芍素 3-O-α-<小>L-阿拉伯吡喃糖基-（1→3）-α-<小>L-鼠李糖基-（1→2）-α-<小>L-阿拉伯吡喃糖苷（4）和赤芍素 3-O-（3、4-二-O-乙酰基-α-L-阿拉伯吡喃糖基）-(1→3)-α-L-鼠李糖基-(1→2)-α-L-阿拉伯吡喃糖苷 (5)，在剂量为 200 毫克/千克时，对血浆甘油三酯的升高有抑制作用。

  DOI：

  10.1248/cpb.57.198

文献信息

• Vaccine Compositions For Marburg Virus
  申请人：Pathak Ashish Kumar

  公开号：US20120136142A1

  公开（公告）日：2012-05-31

  Methods and immunogenic compositions for generating an immune response against Marburg virus are provided. The immunogenic composition includes antigens obtained from a Marburg viral strain in combination with an oleanolic acid triterpene adjuvant.

  本发明提供了用于产生针对马尔堡病毒的免疫反应的方法和免疫原组合物。该免疫原组合物包括从马尔堡病毒株中获得的抗原，结合油酸三萜佐酸类佐剂。
• Triterpene compositions and methods for use thereof
  申请人：Research Development Foundation

  公开号：US20030039705A1

  公开（公告）日：2003-02-27

  The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells. The present application is a continuation-in-part of co-pending U.S. Patent Application Ser. No. 60/099,066, filed Sep. 3, 1998, and a continuation-in-part of U.S. patent application Ser. No. 60/085,997, filed May 19, 1998. The entire text of each of the above-referenced disclosures is specifically incorporated by reference herein without disclaimer.

  本发明提供了从维多利亚金合欢(Acacia victoriae)物种中分离出来的新型皂苷混合物和化合物，以及它们的使用方法。这些化合物可能包含三萜基团，如金合欢酸或齐墩果酸，附着有寡糖和单萜基团。这些混合物和化合物具有与细胞凋亡和细胞毒性调节相关的特性，并对多种肿瘤细胞表现出强效的抗肿瘤作用。本申请是待决美国专利申请号60/099,066的续篇，该专利申请于1998年9月3日提交，并且是待决美国专利申请号60/085,997的续篇，该专利申请于1998年5月19日提交。上述所有引用文件的全部内容都被明确地并入本文，不做免责声明。
• Method of producing ginsenoside 20 (R)-Rh2 and composition of matter thereof
  申请人：Young Jeffrey

  公开号：US20050287230A1

  公开（公告）日：2005-12-29

  The present invention is a method of producing ginsenoside comprising the steps of: (a) producing a predetermined quantity of ginseng dialcohol from an extraction process of ginseng dialcohol; (b) reacting the ginseng dialcohol with a predetermined quantity of acetobromo-α-D-glucose under a predetermined condition; and (c) obtaining a predetermined quantity of ginsenoside Rh 2 . The present invention also provides a composition for enhancing the immune system of a living object comprising a quantity of ginsenoside, a quantity of ursolic acid and a quantity of shikonin. The composition may also comprise a quantity of panaxans, astragalan, and/or lentinan. The ginsenoside 20(R)-Rh 2 , ursolic acid, shikonin, panaxans, astragalan and lentinan have an effective range between 0.001 mg/kg and 0.1 mg/kg, 0.5 mg/kg and 10 mg/kg, 0.5 mg/kg and 10 mg/kg, 0.1 mg/kg and 1 mg/kg, 0.1 mg/kg and 1 mg/kg, and 0.1 mg/kg and 1 mg/kg respectively.

  本发明涉及一种生产人参皂苷的方法，包括以下步骤：（a）从人参二醇的提取过程中生产出预定量的人参二醇；（b）在预定条件下将人参二醇与预定量的乙酰溴-α-D-葡萄糖反应；（c）获得预定量的人参皂苷Rh2。本发明还提供了一种增强生物体免疫系统的组合物，包括一定量的人参皂苷、一定量的熊果酸和一定量的赤芍。该组合物还可以包括一定量的人参皂苷、黄芪苷和/或香菇多糖。人参皂苷20（R）-Rh2、熊果酸、赤芍、人参皂苷、黄芪苷和香菇多糖在0.001 mg/kg至0.1 mg/kg、0.5 mg/kg至10 mg/kg、0.5 mg/kg至10 mg/kg、0.1 mg/kg至1 mg/kg、0.1 mg/kg至1 mg/kg和0.1 mg/kg至1 mg/kg之间具有有效范围。
• COMPOSITION COMPRISING ISCOM PARTICLES AND LIVE MICRO-ORGANISMS
  申请人：Morein Bror

  公开号：US20110081378A1

  公开（公告）日：2011-04-07

  Iscom particles can be used as an adjuvant for preparing of an antigenic composition which comprises live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A composition may comprise at least one iscom particle and one or more live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A kit can comprise at least one compartment containing at least one living organism and at least one compartment containing at least one iscom particle.

  Iscom颗粒可用作制备抗原成分的佐剂，该成分包括活体微生物和/或死亡微生物和/或抗原分子。该成分可以包括至少一个Iscom颗粒和一个或多个活体微生物和/或死亡微生物和/或抗原分子。一种工具包可以包括至少一个隔间，其中包含至少一个生物体和至少一个隔间，其中包含至少一个Iscom颗粒。
• COMPOSITIONS COMPRISING ISCOM PARTICLES AND LIVE MICRO-ORGANISMS
  申请人：NOVAVAX AB

  公开号：US20160114034A1

  公开（公告）日：2016-04-28

  Iscom particles can be used as an adjuvant for preparing of an antigenic composition which comprises live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A composition may comprise at least one iscom particle and one or more live micro-organisms and/or killed micro-organisms and/or antigenic molecules. A kit can comprise at least one compartment containing at least one living organism and at least one compartment containing at least one iscom particle.

  Iscom颗粒可用作制备抗原组分的佐剂，该组分包括活的微生物和/或杀死的微生物和/或抗原分子。组分可以包括至少一个iscom颗粒和一个或多个活的微生物和/或杀死的微生物和/或抗原分子。套件可以包括至少一个隔间，其中至少包含一个活生物和至少一个隔间，其中至少包含一个iscom颗粒。