3,3'-二羟基-7',8'-二脱氢-5,6,7,8-四氢-5,6-环氧-β,β-胡萝卜烯-8-酮 | 81306-52-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,3'-二羟基-7',8'-二脱氢-5,6,7,8-四氢-5,6-环氧-β,β-胡萝卜烯-8-酮
• 英文名称: (3E,5E,7E,9E,11E,13E,15E)-18-(4-hydroxy-2,6,6-trimethylcyclohexen-1-yl)-1-(4-hydroxy-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl)-3,7,12,16-tetramethyloctadeca-3,5,7,9,11,13,15-heptaen-17-yn-2-one
• CAS: 81306-52-7
• 化学式: C₄₀H₅₄O₄
• 分子量: 598.9
• InChiKey: CNOIXMULOQWVGR-XFULSKPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
  申请人：Lockwood Fournier Samuel

  公开号：US20050143475A1

  公开（公告）日：2005-06-30

  A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent.

  一种治疗受试者缺血再灌注损伤的方法。该方法可能包括向受试者施用有效量的药学上可接受的配方。药学上可接受的配方可能包括类胡萝卜素的合成类似物或衍生物。受试者可能被施用类胡萝卜素的类似物或衍生物，可以单独使用，也可以与另一种类胡萝卜素的类似物或衍生物或共抗氧化剂配方结合使用。类胡萝卜素的类似物可能包括具有7到14个双键的共轭聚烯烃。共轭聚烯烃可能包括至少一个取代基的无环烯烃和/或至少一个取代基的环状环。在某些实施例中，类胡萝卜素的类似物或衍生物可能包括至少一个取代基。