4-ethyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole | 234093-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-ethyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole
• 英文别名: 4-Ethyl-1,3,5-tris(4-methoxyphenyl)pyrazole
• CAS: 234093-26-6
• 化学式: C₂₆H₂₆N₂O₃
• 分子量: 414.504
• InChiKey: RKRMCTUXMWCXEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-ethyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到4-[1,3-bis(4-hydroxyphenyl)-4-ethylpyrazol-5-yl]phenol
  参考文献：
  名称：

  Pyrazole Ligands:  Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

  摘要：

  We have found that certain tetrasubstituted pyrazoles are high-affinity ligands for the estrogen receptor (ER) (Fink et al. Chem. Biol. 1999, 6, 205-219) and that one pyrazole is considerably more potent as an agonist on the ER alpha than on the ER beta subtype (Sun et al. Endocrinology 1999, 140, 800-804). To investigate what substituent pattern provides optimal ER binding affinity and the greatest enhancement of potency as an ER alpha -selective agonist, we prepared a number of tetrasubstituted pyrazole analogues with defined variations at certain substituent positions. Analysis of their binding affinity pattern shows that a C(4)-propyl substituent is optimal and that a p-hydroxyl group on the N(1)-phenyl group also enhances affinity and selectivity for ER alpha. The best compound in this series, a propylpyrazole triol (PPT, compound 4g), binds to ER alpha with high affinity (ca. 50% that of estradiol), and it has a 410-fold binding affinity preference for ER alpha. It also activates gene transcription only through ER alpha. Thus, this compound represents the first ER alpha -specific agonist. We investigated the molecular basis for the exceptional ER alpha binding affinity and potency selectivity of pyrazole 4g by a further study of structure-affinity relationships in this series and by molecular modeling. These investigations suggest that the pyrazole triols prefer to bind to ER alpha with their C(3)-phenol in the estradiol A-ring binding pocket and that binding selectivity results from differences in the interaction of the pyrazole core and C(4)-propyl group with portions of the receptor where ER alpha has a smaller residue than ER beta. These ER subtype-specific interactions and the ER subtype-selective ligands that can be derived from them should prove useful in defining those biological activities in estrogen target cells that can be selectively activated through ER alpha.

  DOI：

  10.1021/jm000170m
• 作为产物：
  描述：

  4'-甲氧基苯丁酮 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 4-ethyl-1,3,5-tris(4-methoxyphenyl)-1H-pyrazole
  参考文献：
  名称：

  Pyrazole Ligands:  Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

  摘要：

  We have found that certain tetrasubstituted pyrazoles are high-affinity ligands for the estrogen receptor (ER) (Fink et al. Chem. Biol. 1999, 6, 205-219) and that one pyrazole is considerably more potent as an agonist on the ER alpha than on the ER beta subtype (Sun et al. Endocrinology 1999, 140, 800-804). To investigate what substituent pattern provides optimal ER binding affinity and the greatest enhancement of potency as an ER alpha -selective agonist, we prepared a number of tetrasubstituted pyrazole analogues with defined variations at certain substituent positions. Analysis of their binding affinity pattern shows that a C(4)-propyl substituent is optimal and that a p-hydroxyl group on the N(1)-phenyl group also enhances affinity and selectivity for ER alpha. The best compound in this series, a propylpyrazole triol (PPT, compound 4g), binds to ER alpha with high affinity (ca. 50% that of estradiol), and it has a 410-fold binding affinity preference for ER alpha. It also activates gene transcription only through ER alpha. Thus, this compound represents the first ER alpha -specific agonist. We investigated the molecular basis for the exceptional ER alpha binding affinity and potency selectivity of pyrazole 4g by a further study of structure-affinity relationships in this series and by molecular modeling. These investigations suggest that the pyrazole triols prefer to bind to ER alpha with their C(3)-phenol in the estradiol A-ring binding pocket and that binding selectivity results from differences in the interaction of the pyrazole core and C(4)-propyl group with portions of the receptor where ER alpha has a smaller residue than ER beta. These ER subtype-specific interactions and the ER subtype-selective ligands that can be derived from them should prove useful in defining those biological activities in estrogen target cells that can be selectively activated through ER alpha.

  DOI：

  10.1021/jm000170m

文献信息

• [EN] ESTROGEN RECEPTOR LIGANDS<br/>[FR] LIGANDS SE LIANT AUX RECEPTEURS D'OESTROGENES
  申请人：UNIV ILLINOIS

  公开号：WO2000019994A1

  公开（公告）日：2000-04-13

  This invention provides non-steroidal estrogen receptor ligands having a modular structure that is amenable to solid phase synthesis and the application of combinatorial synthetic methods to prepare these estrogen receptor ligands. ER ligands of this invention consist of a core scaffold that is a carbocyclic or heterocyclic-5-member ring that has two double bonds or a 6-member aromatic ring. A plurality of selected substituents are bonded to the ring substantially independently of other substituents. The modular structure of these compounds allows for synthesis of a very large numer of substituent structural variations, substituent combinations and substituent positioning on the core. The structural variants of the ER ligands of this invention exhibit a spectrum of selective affinities for ERα and ERβ and a spectrum of agonist/antagonist properties.