4-(4-aminobutyl)-4'-methyl-2,2'-bipyriridine | 115021-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-aminobutyl)-4'-methyl-2,2'-bipyriridine
• 英文别名: 4-(4-aminobutyl)-4'-methyl-2,2'-bipyridine；4-[2-(4-Methylpyridin-2-yl)pyridin-4-yl]butan-1-amine
• CAS: 115021-71-1
• 化学式: C₁₅H₁₉N₃
• 分子量: 241.336
• InChiKey: OBQYJADXOFJWAY-UHFFFAOYSA-N

物化性质

• 沸点：
  408.8±45.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-aminobutyl)-4'-methyl-2,2'-bipyriridine 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-{2-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butylcarbamoyl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
  参考文献：
  名称：

  Building Blocks for Ribozyme Mimics:  Conjugates of Terpyridine and Bipyridine with Nucleosides

  摘要：

  The incorporation of the 2,2':6',2 ''-terpyridyl (terpy) complex of Cu(II) into a deoxyoligonucleotide has led to a functional mimic of ribozymes. The resulting mimic can cleave target RNA in a sequence-directed manner by a hydrolytic mechanism. Here we describe the synthesis and characterization of four modified nucleoside phosphoramidite reagents (7, 10, 14, and 18) that contain pendant 2,2'-bipyridine or terpy ligands. The ligands are attached either to the nucleobase (7, 10) or to the sugar (14, 18). Nucleobase modification was carried out at the C-5 position of 2'-deoxyuridine (dU). One route to sugar modification was performed by synthesis of 18, a 1'-functionalized analog of dU based on 1-[3-deoxy-beta-D-psicofuranosyl]uracil. Another route to sugar functionaliztion resulted in 14, a 2'-O-alkyl derivative of adenosine. These modified nucleosides are building blocks for ribozyme mimics. They are designed to deliver hydrolytically active metal complexes across either the major groove (7, 10) or the minor groove (14, 18) of an RNA/DNA duplex.

  DOI：

  10.1021/jo9518213
• 作为产物：
  描述：

  4,4'-二甲基-2,2'-联吡啶 在 sodium tetrahydroborate 、 正丁基锂 、 氢溴酸 、 一水合肼 、 二异丙胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.5h， 生成 4-(4-aminobutyl)-4'-methyl-2,2'-bipyriridine
  参考文献：
  名称：

  Synthesis of side-chain derivatives of 2,2'-bipyridine

  摘要：

  DOI：

  10.1021/jo00268a042

文献信息

• Detecting the presence of analytes in a sample
  申请人：IGEN, INC.

  公开号：EP0647849A2

  公开（公告）日：1995-04-12

  Method for detecting the presence of an analyte in a sample by immobilising the analyte, removing the immobilised analyte from the sample, contacting the removed immobilised analyte with a labelled antibody able to form a complex containing the analyte, and detecting the presence of the analyte by detecting the presence of the complexed labelled antibody. Kits and a reactor suitable for use with the method are also provided.

  检测样品中是否存在分析物的方法：固定分析物，从样品中移除固定的分析物，将移除的固定分析物与能够形成含有分析物的复合物的标记抗体接触，通过检测复合物标记抗体的存在来检测分析物的存在。此外，还提供了适用于该方法的试剂盒和反应器。
• Method and device for determining concentration of dioxins
  申请人：SATAKE CORPORATION

  公开号：US20020052051A1

  公开（公告）日：2002-05-02

  A method for determining the concentration of dioxins present in a sample comprises the steps of chemically linking a hapten having a structure mimic to a part of the structures of dioxins with a ruthenium complex to thus form an antigen; incubating the resulting antigen together with an antibody fixed to or immobilized on an electrode to thus induce an antigen-antibody reaction; oxidizing or reducing the ruthenium complex by applying an electric voltage to the reaction product through the electrode to thus induce electrolytic light emission; and observing the electrolytically emitted light rays to quantitatively determine the amount of the antigen and to thus evaluate the concentration of the dioxins present in the sample. The present invention permits the elimination of the use of any reagent such as hydrogen peroxide required for the chemical luminescence, the highly sensitive analysis of dioxins and the miniaturization of the device to be used in the analysis of dioxins.

  一种测定样品中二恶英浓度的方法包括以下步骤：将具有与二恶英部分结构相似的结构的单体与钌络合物化学连接，从而形成抗原；将生成的抗原与固定在或固定在电极上的抗体一起孵育，从而诱导抗原-抗体反应；通过电极对反应产物施加电压，氧化或还原钌络合物，从而诱导电解发光；观察电解发光的光线，定量确定抗原的数量，从而评估样品中二恶英的浓度。本发明无需使用化学发光所需的任何试剂（如过氧化氢），可对二恶英进行高灵敏度分析，并使用于分析二恶英的装置小型化。
• CIANA, LEOPOLDO DELLA;HAMACHI, ITARU;MEYER, THOMAS J., J. ORG. CHEM., 54,(1989) N, C. 1731-1735
  作者：CIANA, LEOPOLDO DELLA、HAMACHI, ITARU、MEYER, THOMAS J.

  DOI：——

  日期：——
• ELECTROCHEMILUMINESCENT ASSAYS
  申请人：IGEN, INC. (a California corporation)

  公开号：EP0265519A1

  公开（公告）日：1988-05-04
• EP0265519A4
  申请人：——

  公开号：EP0265519A4

  公开（公告）日：1990-05-14