1,9-Bis[[tert-butyl(dimethyl)silyl]oxy]-2,4,6,8-tetramethylnonane-3,5,7-trione | 134986-97-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,9-Bis[[tert-butyl(dimethyl)silyl]oxy]-2,4,6,8-tetramethylnonane-3,5,7-trione
• CAS: 134986-97-3
• 化学式: C₂₅H₅₀O₅Si₂
• 分子量: 486.84
• InChiKey: HRJCOISARAEJSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.28
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,9-Bis[[tert-butyl(dimethyl)silyl]oxy]-2,4,6,8-tetramethylnonane-3,5,7-trione 在 氢氟酸 、 sodium methylate 、 氢化钾 作用下， 以 甲醇 、 氨 、 乙腈 为溶剂， 反应 36.0h， 生成 (3S,4R,5S,9S,10R,11S)-3,5,9,11-Tetramethyl-1,7-dioxa-spiro[5.5]undecane-4,10-diol
  参考文献：
  名称：

  Multiple equilibration strategies in synthesis. Stereocontrolled synthesis of polypropionate fragments

  摘要：

  A multiple equilibration strategy as a general approach to asymmetric synthesis has been demonstrated. The generation, multiple equilibration, and manipulation of methyl-substituted 4,10-diketo-1,7-dioxaspiro[5.5]-undecanes has led to the synthesis of polypropionate fragments containing tetrahydropyran rings containing seven contiguous stereocenters in only five steps with complete stereocontrol.

  DOI：

  10.1021/jo00058a003
• 作为产物：
  描述：

  3-tert-butyldimethylsilyloxy-2-methylpropanal 、 3-戊酮 生成 1,9-Bis[[tert-butyl(dimethyl)silyl]oxy]-2,4,6,8-tetramethylnonane-3,5,7-trione
  参考文献：
  名称：

  Multiple equilibration strategies in synthesis. Stereocontrolled synthesis of polypropionate fragments

  摘要：

  A multiple equilibration strategy as a general approach to asymmetric synthesis has been demonstrated. The generation, multiple equilibration, and manipulation of methyl-substituted 4,10-diketo-1,7-dioxaspiro[5.5]-undecanes has led to the synthesis of polypropionate fragments containing tetrahydropyran rings containing seven contiguous stereocenters in only five steps with complete stereocontrol.

  DOI：

  10.1021/jo00058a003

文献信息

• Multiple equilibration strategies in synthesis. Stereocontrolled synthesis of polypropionate fragments
  作者：Yun Bo Zhao、Norman E. Pratt、Mary Jane Heeg、Kim F. Albizati

  DOI：10.1021/jo00058a003

  日期：1993.3

  A multiple equilibration strategy as a general approach to asymmetric synthesis has been demonstrated. The generation, multiple equilibration, and manipulation of methyl-substituted 4,10-diketo-1,7-dioxaspiro[5.5]-undecanes has led to the synthesis of polypropionate fragments containing tetrahydropyran rings containing seven contiguous stereocenters in only five steps with complete stereocontrol.