7-chloro-1,2-dihydro-2,2,4,8-tetramethylquinoline | 877160-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-1,2-dihydro-2,2,4,8-tetramethylquinoline
• 英文别名: 7-Chloro-2,2,4,8-tetramethyl-1H-quinoline
• CAS: 877160-52-6
• 化学式: C₁₃H₁₆ClN
• 分子量: 221.73
• InChiKey: CBHIGFLCKFTNPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-chloro-1,2-dihydro-2,2,4,8-tetramethylquinoline 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists

  摘要：

  A series of tetrahydroquinoline derivatives were synthesized and profiled for their ability to act as glucocorticoid receptor selective modulators. Structure-activity relationships of the tetrahydroquinoline B-ring lead to the discovery of orally available GR-selective agonists with high in vivo activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.093
• 作为产物：
  描述：

  3-氯-2-甲基苯胺 、 丙酮 在 碘 作用下， 反应 15.0h， 生成 7-chloro-1,2-dihydro-2,2,4,8-tetramethylquinoline
  参考文献：
  名称：

  Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists

  摘要：

  A series of tetrahydroquinoline derivatives were synthesized and profiled for their ability to act as glucocorticoid receptor selective modulators. Structure-activity relationships of the tetrahydroquinoline B-ring lead to the discovery of orally available GR-selective agonists with high in vivo activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.093

文献信息

• [EN] INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS MODULATEURS DE RÉCEPTEURS INTRACELLULAIRES ET PROCÉDÉS DE PRODUCTION ET D'UTILISATION DE CEUX-CI
  申请人：LIGAND PHARM INC

  公开号：WO2006019716A1

  公开（公告）日：2006-02-23

  This invention relates to compounds of Formula I, II or III with the definitions of R1-R10 according to claim 1 that bind to intracellular receptors and/or modulate activity of intracellular receptors, and to methods for making and using such compounds.

  这项发明涉及具有根据权利要求1中R1-R10的定义的化合物I、II或III，这些化合物与细胞内受体结合和/或调节细胞内受体活性，并涉及制备和使用这类化合物的方法。
• INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS
  申请人：Higuchi I. Robert

  公开号：US20070254917A1

  公开（公告）日：2007-11-01

  This invention relates to compounds that bind to intracellular receptors and/or modulate activity of intracellular receptors, and to methods for making and using such compounds.

  本发明涉及与细胞内受体结合和/或调节细胞内受体活性的化合物，以及制备和使用这种化合物的方法。
• Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists
  作者：Andrew R. Hudson、Robert I. Higuchi、Steven L. Roach、Mark E. Adams、Angela Vassar、Peter M. Syka、Dale E. Mais、Jeffrey N. Miner、Keith B. Marschke、Lin Zhi

  DOI：10.1016/j.bmcl.2011.01.093

  日期：2011.3

  A series of tetrahydroquinoline derivatives were synthesized and profiled for their ability to act as glucocorticoid receptor selective modulators. Structure-activity relationships of the tetrahydroquinoline B-ring lead to the discovery of orally available GR-selective agonists with high in vivo activity. (C) 2011 Elsevier Ltd. All rights reserved.