ent-10-Hydroxy-9-methyl-13α-isopropyl-17-nor-podocarpansaeure-(16)-lacton | 2326-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ent-10-Hydroxy-9-methyl-13α-isopropyl-17-nor-podocarpansaeure-(16)-lacton
• 英文别名: Dihydroabietinsaeure-γ-lacton；(1S,2R,5R,7R,10R,11R)-2,11-dimethyl-5-propan-2-yl-15-oxatetracyclo[9.3.2.01,10.02,7]hexadecan-16-one
• CAS: 2326-18-3
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: JMDLYACWFYZOQW-NGIBWZRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ent-10-Hydroxy-9-methyl-13α-isopropyl-17-nor-podocarpansaeure-(16)-lacton 在 氢氧化钾 作用下， 以 二乙二醇 为溶剂， 生成 ent-9-methyl-20-nor-13βH-abieten-(1(10))-oic acid-(19)
  参考文献：
  名称：

  Tahara,A. et al., Chemical and pharmaceutical bulletin, 1972, vol. 20, # 3, p. 459 - 468

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 铂 作用下， 生成 ent-10-Hydroxy-9-methyl-13α-isopropyl-17-nor-podocarpansaeure-(16)-lacton
  参考文献：
  名称：

  Clinico-pathological profile of pediatric lymphadenopathy

  摘要：

  Objective: To study the clinico-pathological profile of significant pediatric peripheral lymphadenopathy and to arrrive at an etiological diagnosis. Methods: Prospective study in a tertiary care hospital setting. One hundred consecutive children reporting to pediatric OPD from 1 January 1995 to 31 December 1998, aged 1 month to 12 years were studied. Results: The commonest aetiology diagnosed was tubercular lymphadenitis in 35% cases, followed by chronic tonsillopharyngitis in 15% cases. Lymphomas, AIDS and infectious mononucleosis constituted 3, 2 and 1 cases each. Aetiology could not be ascertained in 44 (44%) children even after detailed haematological, microbiological, radiological and serological investigations. FNAC's sensitivity and specificity as compared to 'gold standard of excision lymph node biopsy was 94% and 100% respectively. Conclusion: Tubercular lymphadenitis was the commonest treatable entity of significant pediatric peripheral lymphadenopathy. A majority of the cases even after thorough evaluation, remained undiagnosed. FNAC as a diagnostic modality is almost as sensitive and as specific as excision lymph node biopsy when an adequate aspirate is examined by expert eyes.

  DOI：

  10.1007/bf02724385

文献信息

• Steroids and related natural products—X
  作者：G.R. Pettit、B. Green、T.R. Kasturi、U.R. Ghatak

  DOI：10.1016/s0040-4020(01)92749-8

  日期：1962.1

  Boron trifluoride etherate-lithium aluminum hydride reduction of 12β-hydroxy-14ξ-rosane 16-carboxylic acid lactone (IIa), dihydroabietic γ-lactone (IIIa) and 3β-hydroxy-7-oxo-7a-oxa-B- homo-5α-cholestane (Xa) was found to yield the corresponding (IIb and IIIb) and oxepane (Xb, after acetylation) derivatives. Similar reduction of several lactones prepared from primary alcohols resulted in essentially

  三氟化硼醚化物-氢化铝锂还原12β-羟基-14ξ-罗烷16-羧酸内酯（IIa），二氢松香γ-内酯（IIIa）和3β-羟基-7-氧代-7a-oxa-B-homo-5α发现-胆甾烷（Xa）产生相应的（IIb和IIIb）和氧杂环丁烷（乙酰化后的Xb）衍生物。由伯醇制备的几种内酯的类似还原导致基本上完全转化为它们各自的二醇。例如，在还原3-oxo-3a-oxa-A-homo-5α-androstane（VII）之后，仅分离出3,4-二羟基-3,4-seco-5α-雄烷（IX）。本研究表明，随着与酯烷基氧部分相邻的支链的增加，酯的三氟化硼-氢化铝锂的还原将越来越有利于醚的形成。
• Polyterpene und Polyterpenoide LXXVIII. Beiträge zur Kenntnis der Lage der Carboxylgruppe und der Doppelbindungen bei der Abietinsäure
  作者：L. Ruzicka、H. Waldmann、Paul J. Meier、H. Hösli

  DOI：10.1002/hlca.19330160122

  日期：——
• Resin Acids. The Structure of the Lactone of Hydroxytetrahydroabietic Acid¹
  作者：Richard F. B. Cox

  DOI：10.1021/ja01234a005

  日期：1944.6
• Velluz et al., Bulletin de la Societe Chimique de France, 1954, p. 401,406
  作者：Velluz et al.

  DOI：——

  日期：——
• Synthesis of fichtelite and related derivatives of abietane
  作者：Albert W. Burgstahler、John N. Marx

  DOI：10.1021/jo01258a006

  日期：1969.6