(3-methoxycarbonyl-2-oxo-cyclopentyl)-glyoxylic acid methyl ester | 854419-13-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-methoxycarbonyl-2-oxo-cyclopentyl)-glyoxylic acid methyl ester
• 英文别名: Opt.-inakt. (2-Oxo-3-methoxycarbonyl-cyclopentyl)-glyoxylsaeure-methylester；(3-Methoxycarbonyl-2-oxo-cyclopentyl)-glyoxylsaeure-methylester；Methyl 3-(2-methoxy-2-oxoacetyl)-2-oxocyclopentane-1-carboxylate；methyl 3-(2-methoxy-2-oxoacetyl)-2-oxocyclopentane-1-carboxylate
• CAS: 854419-13-9
• 化学式: C₁₀H₁₂O₆
• 分子量: 228.202
• InChiKey: GWSASGWZIWUCBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3-methoxycarbonyl-2-oxo-cyclopentyl)-glyoxylic acid methyl ester 在 水 、 铂 作用下， 生成 trans-3-Carboxy-cyclopentanessigsaeure 、 cis-3-(carboxymethyl)cyclopentanecarboxylic acid
  参考文献：
  名称：

  The OxyArm™ — a new minimal contact oxygen delivery system for mouth or nose breathing

  摘要：

  Purpose: To describe the development and performance of a new minimal contact oxygen (O-2) delivery system for both nasal and oral breathing, with capnographic capabilities,Methods: The development and design challenges of the OxyArm(TM) (OA) prototype are described, The innovative design utilizes a headset with a semi-rigid boom and an O-2 diffuser. The OA was compared to the Venturi mask in eight healthy adults after informed consent. Inspired O-2 fractions were measured in the hypopharynx using continuous gas sampling at low to high O-2 flow rates. Mean data were compared using two-tailed paired t tests with significance set at 0.05,Results: The measured inspired 0 2 concentration was higher in the OA at 2 (26.3 +/- 2.5 vs 23.3 +/- 0.5, P <0.01) and 6 L.min(-1) (33.5 +/- 33 vs 28.8 +/- 1.2, P <0.01) flow rates, At 12 L.min(-1), the O-2 concentration was less in the OA (39.2 +/- 6.3 vs 46.0 +/- 2.7, P <0.02). All subjects found both systems comfortable for the short duration of the study.Conclusions: The OA delivered predictable concentrations of O-2 over low to medium flow rates. This system is comfortable, easy to use, non-obtrusive, odorless, and latex-free. The ability to monitor capnography makes this device ideal for monitored anesthesia care or in other settings (intensive care) where monitoring of respiration is warranted, This device does not contact the face and thus may be ideal for pediatric patients and those on long-term home O-2 therapy, Further clinical trials in these areas are warranted.

  DOI：

  10.1007/bf03020531
• 作为产物：
  描述：

  草酸二甲酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium methylate 、 甲苯 作用下， 生成 (3-methoxycarbonyl-2-oxo-cyclopentyl)-glyoxylic acid methyl ester
  参考文献：
  名称：

  The OxyArm™ — a new minimal contact oxygen delivery system for mouth or nose breathing

  摘要：

  Purpose: To describe the development and performance of a new minimal contact oxygen (O-2) delivery system for both nasal and oral breathing, with capnographic capabilities,Methods: The development and design challenges of the OxyArm(TM) (OA) prototype are described, The innovative design utilizes a headset with a semi-rigid boom and an O-2 diffuser. The OA was compared to the Venturi mask in eight healthy adults after informed consent. Inspired O-2 fractions were measured in the hypopharynx using continuous gas sampling at low to high O-2 flow rates. Mean data were compared using two-tailed paired t tests with significance set at 0.05,Results: The measured inspired 0 2 concentration was higher in the OA at 2 (26.3 +/- 2.5 vs 23.3 +/- 0.5, P <0.01) and 6 L.min(-1) (33.5 +/- 33 vs 28.8 +/- 1.2, P <0.01) flow rates, At 12 L.min(-1), the O-2 concentration was less in the OA (39.2 +/- 6.3 vs 46.0 +/- 2.7, P <0.02). All subjects found both systems comfortable for the short duration of the study.Conclusions: The OA delivered predictable concentrations of O-2 over low to medium flow rates. This system is comfortable, easy to use, non-obtrusive, odorless, and latex-free. The ability to monitor capnography makes this device ideal for monitored anesthesia care or in other settings (intensive care) where monitoring of respiration is warranted, This device does not contact the face and thus may be ideal for pediatric patients and those on long-term home O-2 therapy, Further clinical trials in these areas are warranted.

  DOI：

  10.1007/bf03020531

文献信息

• The OxyArm™ — a new minimal contact oxygen delivery system for mouth or nose breathing
  作者：Elizabeth Ling、Lee McDonald、Tim R. J. Dinesen、Donald DuVall

  DOI：10.1007/bf03020531

  日期：2002.3

  Purpose: To describe the development and performance of a new minimal contact oxygen (O-2) delivery system for both nasal and oral breathing, with capnographic capabilities,Methods: The development and design challenges of the OxyArm(TM) (OA) prototype are described, The innovative design utilizes a headset with a semi-rigid boom and an O-2 diffuser. The OA was compared to the Venturi mask in eight healthy adults after informed consent. Inspired O-2 fractions were measured in the hypopharynx using continuous gas sampling at low to high O-2 flow rates. Mean data were compared using two-tailed paired t tests with significance set at 0.05,Results: The measured inspired 0 2 concentration was higher in the OA at 2 (26.3 +/- 2.5 vs 23.3 +/- 0.5, P <0.01) and 6 L.min(-1) (33.5 +/- 33 vs 28.8 +/- 1.2, P <0.01) flow rates, At 12 L.min(-1), the O-2 concentration was less in the OA (39.2 +/- 6.3 vs 46.0 +/- 2.7, P <0.02). All subjects found both systems comfortable for the short duration of the study.Conclusions: The OA delivered predictable concentrations of O-2 over low to medium flow rates. This system is comfortable, easy to use, non-obtrusive, odorless, and latex-free. The ability to monitor capnography makes this device ideal for monitored anesthesia care or in other settings (intensive care) where monitoring of respiration is warranted, This device does not contact the face and thus may be ideal for pediatric patients and those on long-term home O-2 therapy, Further clinical trials in these areas are warranted.