1,3,3,4-tetramethylcyclohex-1-ene | 70092-37-4

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 1,3,3,4-tetramethylcyclohex-1-ene
• 英文别名: 1,3,3,4-tetramethyl-cyclohexene；1,3,3,4-Tetramethyl-cyclohexen；6-Methyl-β-cyclogeraniolen；1,3,3,4-Tetramethylcyclohexen；1,3,3,4-tetramethylcyclohexene
• CAS: 70092-37-4
• 化学式: C₁₀H₁₈
• 分子量: 138.253
• InChiKey: KFADPHIJZPOZOB-UHFFFAOYSA-N

物化性质

• 沸点：
  158-160 °C(Press: 720 Torr)
• 密度：
  0.8162 g/cm3(Temp: 22 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,3,3,4-tetramethylcyclohex-1-ene 生成 6-Methyl-β-cyclolavandulal
  参考文献：
  名称：

  Prins Products from 6-Methyl-β-cyclogeraniolene and Synthesis of 6-Methyl-β-cyclolavandulylideneacetone

  摘要：

  DOI：

  10.1246/bcsj.35.818
• 作为产物：
  描述：

  3,3,4-trimethylcyclohexanone 在 草酸 、 magnesium 作用下， 反应 5.0h， 生成 1,3,3,4-tetramethylcyclohex-1-ene
  参考文献：
  名称：

  （+）-（2 S，6 S）-反式-α-Irone和（-）-（2 S，6 S）-反式-γ-Irone的合成†

  摘要：

  （+）-（2 S，6 S）-反-α-irone（（+）-1）和（-）-（2 S，6 S）-反-γ-酮（- ）-2）已与ca合成。（-）-（S）-3和but-3-yn-2-one的烯反应，可得到70％ee 。

  DOI：

  10.1002/hlca.19890720713

文献信息

• Veilchenriechstoffe. 17 Mitteilung. Über den Abbau des Tetrahydro-irons
  作者：L. Ruzicka、C. F. Seidel、W. Brugger

  DOI：10.1002/hlca.19470300735

  日期：1947.12.1
• Anatomical position of the Vomeronasal Organ in postnatal humans
  作者：Timothy D. Smith、Thomas A. Buttery、Kunwar P. Bhatnagar、Annie M. Burrows、Mark P. Mooney、Michael I. Siegel

  DOI：10.1016/s0940-9602(01)80209-0

  日期：2001.9

  In the last decade or so, there has been a renewed interest in the adult human vomeronasal organ (VNO). Studies have yielded sometimes disparate findings about the microscopic structure of the organ and its supporting tissues. Such varied descriptions may be due to examination of different regions of the VNO, individual variation of VNOs among humans, or the presence of multiple, non-homologous structures that bear false resemblance to the human VNO. A histological description of the spatial relationship of the human VNO to other nasal septal elements is needed to ensure that all investigators are examining the same regions and homologous structures. Histologically sectioned nasal septa from 22 human cadavers (1 child, 21 adults) were examined grossly and by light microscopy for the VNO. Using histological sections, the position of the VNO relative to other structures was estimated. Sections containing the VNO were retrospectively compared to scaled photographic slides of the unsectioned septa to identify surface landmarks. Human VNOs varied in anteroposterior and superoinferior position relative to the anterior nasal spine and the nasal cavity floor. In the absence of a visible duct opening, the only reliable surface marker, no consistent surface markings were noted for precise location. VNOs were frequently found superior to swellings associated with the paraseptal and/or septal cartilages. Such findings demonstrate that the human VNO is positionally variable, which may have contributed to previous conflicting findings on presence versus absence. Furthermore, our findings support recent suggestions that the VNO may have been misidentified by some investigators, and that its opening can be easily confused with other structures.
• HELMLINGER, DANIEL;FRATER, GEORG, HELV. CHIM. ACTA, 72,(1989) N, C. 1515-1521
  作者：HELMLINGER, DANIEL、FRATER, GEORG

  DOI：——

  日期：——
• Prins Products from 6-Methyl-β-cyclogeraniolene and Synthesis of 6-Methyl-β-cyclolavandulylideneacetone
  作者：Atsuaki Arai、Iwao Ichikizaki

  DOI：10.1246/bcsj.35.818

  日期：1962.5
• Synthesis of(+)-(2<i>S</i>, 6<i>S</i>)-<i>trans</i>-α-Irone and of(-)-(2<i>S</i>, 6<i>S</i>)-<i>trans</i>-γ-Irone
  作者：Daniel Helmlinger、Georg Fráter

  DOI：10.1002/hlca.19890720713

  日期：1989.11.1

  A 3:1 mixture of (+)-(2S, 6S)-trans-α-irone ((+)-1) and (−)-(2S, 6S)-trans-γ-irone (−)-2) has been synthesized with ca. 70% e. e. by the ene reaction of (−)-(S)-3 and but-3-yn-2-one.

  （+）-（2 S，6 S）-反-α-irone（（+）-1）和（-）-（2 S，6 S）-反-γ-酮（- ）-2）已与ca合成。（-）-（S）-3和but-3-yn-2-one的烯反应，可得到70％ee 。