甲基丙二酸氢 | 16695-14-0

• 物质功能分类: 化学试剂 - 有机试剂 - 脂肪酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基丙二酸氢
• 中文别名: 丙二酸单甲酯
• 英文名称: Malonic acid monomethyl ester
• 英文别名: monomethyl malonate；3-methoxy-3-oxopropanoic acid；3-methoxy-3-oxopropionic acid
• CAS: 16695-14-0
• 化学式: C₄H₆O₄
• mdl: MFCD00667796
• 分子量: 118.089
• InChiKey: PBVZQAXFSQKDKK-UHFFFAOYSA-N

物化性质

• 沸点：
  232℃
• 密度：
  1.128
• 闪点：
  104℃
• 稳定性/保质期：
  常温常压下稳定，避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 安全说明：
  S26,S37
• 危险类别码：
  R36/37/38
• 海关编码：
  2918990090
• 储存条件：
  常温下应密闭避光保存，并置于通风干燥处。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Monomethyl malonate
Product Name:
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

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Section 3. Composition/information on ingredients.
Monomethyl malonate
Ingredient name:
CAS number: 16695-14-0

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Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C4H6O4
Molecular weight: 118.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

概述

甲基丙二酸氢又称为丙二酸单甲酯，是一种有机溶剂。

制备

甲基丙二酸氢可通过丙二酸环(亚)异丙酯与甲醇的一步反应制得。

反应信息

• 作为反应物：
  描述：

  甲基丙二酸氢 以95%的产率得到丙二酸二甲酯
  参考文献：
  名称：

  Process for preparing malonate derivatives or beta -keto esters from epoxide derivatives

  摘要：

  从环氧化物制备丙二酸单酯或β-酮酯的过程包括以下步骤：在钴化合物的催化作用下，将环氧化物与一氧化碳和醇反应，并加入至少一种促进剂以产生β-羟基酯，将β-羟基酯与钴化合物和促进剂分离，然后氧化β-羟基酯以产生丙二酸单酯或β-酮酯。

  公开号：

  US20020035290A1
• 作为产物：
  描述：

  丙二酸二甲酯 在 水 、 potassium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 甲基丙二酸氢
  参考文献：
  名称：

  N-杂环卡宾催化的无环1,3-二羰基的对映选择性α-氨基化。

  摘要：

  在这里，我们描述了一种用于α-取代的无环1,3-酮酰胺和1,3-酰胺基酯的催化对映选择性α-氨基化的方法，该方法提供了具有N-取代的季立体中心和手性N-杂环卡宾（NHC）的产物。该反应基于利用NHC的固有布朗斯台德碱特性，该特性使能催化形成包含烯醇盐和the离子的手性离子对。通过该方法将一系列具有挑战性的开链α-取代的1,3-二羰基胺化，其ee≤99％。

  DOI：

  10.1021/acs.orglett.9b04232
• 作为试剂：
  描述：

  acide (N-dodecyl acetamido)-3 propanoique 在 甲基丙二酸氢 、 sodium 作用下， 以 吡啶 、 甲醇 为溶剂， 以8%的产率得到4-(N-十二烷基乙酰氨基)丁酸甲酯
  参考文献：
  名称：

  Abderrahman, Ben Moufida; Laurent, Eliane; Marquet, Bernard, Bulletin de la Societe Chimique de France, 1988, # 3, p. 571 - 578

  摘要：

  DOI：

文献信息

• A Direct, Versatile, and Chemoselective Synthesis of Vinylogous Bis- and Monourethanes/amides and β-Keto Esters by Aza-Knoevenagel-Type Reactions of Tertiary Amides with Enolates
  作者：Pei-Qiang Huang、Wei Ou

  DOI：10.1002/ejoc.201601326

  日期：2017.1.18

  carbanions generated from methyl ketones, malonic acid monoester, 2-phenylacetate, or (benzylsulfonyl)benzene. Moreover, when higher homologous of acetate was used, beta-keto esters were obtained directly from amides. The method has been applied to the one-step synthesis of several known key intermediates in the total synthesis of alkaloids and quinoline antibiotics. An efficient and mild intramolecular Friedel-Crafts

  报告了对使用常见叔酰胺作为亲电伙伴的 aza-Knoevenagel 型反应的调查的全部细节。该方法基于将稳定的碳负离子亲核试剂添加到原位三氟甲磺酸酐活化的酰胺中。该反应在温和条件下运行，可耐受几个敏感的官能团，包括烯酰胺和 TBSO。值得注意的是，由于酰胺带有更多的反应性酯、氰基和醛基，反应以化学选择性发生在反应性最低的酰胺基上。这种 C=C 键形成中化学选择性的“umpolung”具有挑战性、罕见且具有合成价值。乙烯基双氨基甲酸酯（氮杂-Knoevenagel型缩合产物），乙烯基氨基甲酸酯，和乙烯基酰胺可以通过使用由甲基酮、丙二酸单酯、2-苯基乙酸酯或（苄基磺酰基）苯产生的烯醇化物/碳负离子来合成。此外，当使用更高同系物的乙酸酯时，β-酮酯可直接从酰胺中获得。该方法已应用于生物碱和喹啉类抗生素全合成中几种已知关键中间体的一步合成。使用 Tf2O 作为有效的促进剂，也实现了苯胺酯的有效和温和的分子内
• Scope, Limitations and Mechanistic Analysis of the HyperBTM‐Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols**
  作者：Samuel M. Smith、Mark D. Greenhalgh、Taisiia Feoktistova、Daniel M. Walden、James E. Taylor、David B. Cordes、Alexandra M. Z. Slawin、Paul Ha‐Yeon Cheong、Andrew D. Smith

  DOI：10.1002/ejoc.202101111

  日期：2022.1.11

  isothiourea HyperBTM catalyzes the acylative kinetic resolution of a wide range of tertiary heterocyclic alcohols under mild conditions with high selectivity. The synthetic utility of the methodology has been demonstrated with the preparation of two bioactive targets. Kinetic analysis reveals a fractional reaction order with respect to the alcohol concentration.

  异硫脲 HyperBTM 在温和条件下以高选择性催化多种叔杂环醇的酰化动力学拆分。该方法的合成效用已通过制备两个生物活性靶标得到证明。动力学分析揭示了关于醇浓度的分级反应顺序。
• [EN] PROGRANULIN MODULATORS AND METHODS OF USING THE SAME<br/>[FR] MODULATEURS DE LA PROGRANULINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ARKUDA THERAPEUTICS

  公开号：WO2020252222A1

  公开（公告）日：2020-12-17

  Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).

  本文件提供了调节颗粒蛋白的化合物及其在颗粒蛋白相关疾病中的使用方法，例如额颞痴呆（FTD）。
• An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation
  作者：John Kallikat Augustine、Agnes Bombrun、Balakrishna Ramappa、Chandrakantha Boodappa

  DOI：10.1016/j.tetlet.2012.06.037

  日期：2012.8

  An efficient one-pot synthesis of coumarins mediated by T3P, a mild and low toxic peptide coupling agent, via the Perkin condensation has been demonstrated.

  已经证明了通过珀金（Perkin）缩合反应，由温和低毒的肽偶联剂T3P介导的一锅香豆素的有效合成。
• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF CLOBAZAM AND ITS INTERMEDIATE<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE CLOBAZAM ET SON INTERMÉDIAIRE
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2016151464A1

  公开（公告）日：2016-09-29

  The present invention provides an improved process for the preparation of 8-chloro-1-phenyl- 1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to as the compound (IV)), which is useful as a key intermediate for the synthesis of Clobazam (referred to as the compound (I)) 7-chloro-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione. The process of the present invention further involves transformation of the compound (IV) into Clobazam (I), comprising (a) reacting the compound (II) (as described herein) with monoalkyl malonate in the presence of a coupling agent to obtain the compound (III) (as described herein); followed by the cyclization using a base; (b) reacting the compound-IV (as described herein) obtained from step (a) with methylating agent. The process of the present invention involves formation of novel intermediates methyl 3-((4- chloro-2-(phenylamino)phenyl)amino)-3-oxopropanoate (IlIa) and 3-((4-chloro-2- (phenylamino)phenyl)amino)-3-oxopropanoic acid (V).

  本发明提供了一种改进的制备8-氯-1-苯基-1H-苯并[b][1,4]二氮杂环-2,4(3H,5H)-二酮（以下简称为化合物（IV））的过程，该过程用作合成氯硝安（简称为化合物（I））7-氯-1-甲基-5-苯基-1H-苯并[b][1,4]二氮杂环-2,4(3H,5H)-二酮的关键中间体。本发明的过程还涉及将化合物（IV）转化为氯硝安（I），包括(a)在偶联剂存在下将化合物（II）（如本文所述）与单烷基马隆酸酯反应，以获得化合物（III）（如本文所述）；随后使用碱进行环化；(b)将从步骤(a)中获得的化合物-IV（如本文所述）与甲基化试剂反应。本发明的过程涉及新型中间体甲基3-((4-氯-2-(苯胺基)苯基)氨基)-3-氧代丙酸酯（IlIa）和3-((4-氯-2-(苯胺基)苯基)氨基)-3-氧代丙酸（V）的形成。