butyl methyl propanediate | 79546-83-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: butyl methyl propanediate
• 英文别名: butyl methyl propanedioate；malonic acid butyl ester-methyl ester；Malonsaeure-butylester-methylester；3-O-butyl 1-O-methyl propanedioate
• CAS: 79546-83-1
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: TWHYGPFXAZAPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  butyl methyl propanediate 在 对甲苯磺酰叠氮 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以80%的产率得到butyl methyl 2-diazopropanedioate
  参考文献：
  名称：

  Total Synthesis of (-)-Austalide B. A Generic Solution to Elaboration of the Pyran/p-Cresol/Butenolide Triad

  摘要：

  The toxic meroterpenoid (-)-austalide B has been prepared in its natural form by chemical modification of the readily available optically active enedione 11. Following stereocontrolled Robinson annulation to give 13 and fully regiocontrolled gem-dimethylation of this intermediate, the highly functionalized tetracyclic ortho ester 22 was produced in four additional steps. At this point, it proved an easy matter to obtain 23 by Baeyer-Villiger oxidation. For the purpose of annealing rings E and F, carbomethoxy trinate 41 was prepared and coupled to 42 through the agency of Pd-2(dba)(3) and (furyl)(3)P. With arrival at 39, it proved possible by sequential intramolecular Claisen condensation, O-methylation, and modest warming to produce 50. Deprotection of the secondary hydroxyl and inversion of its configuration delivered synthetic austalide B, which exhibited melting point, specific rotation, infrared, and NMR properties (H-1 and C-13) identical to the natural material obtained from South Africa.

  DOI：

  10.1021/ja00104a012
• 作为产物：
  描述：

  乙酸丁酯 在 乙醚 、 氨 、 sodium amide 作用下， 生成 butyl methyl propanediate
  参考文献：
  名称：

  Hauser; Levine; Kibler, Journal of the American Chemical Society, 1946, vol. 68, p. 27

  摘要：

  DOI：

文献信息

• A mild, rapid and convenient esterification of half esters of malonic acid
  作者：Arie L. Gutman、Aviv Boltanski

  DOI：10.1016/s0040-4039(00)98555-1

  日期：——

  A new method for the esterification of half esters of malonic acid with chloroformates is described. The reaction proceeds the mixed anhydride followed by spontaneous decarboxylation.

  描述了一种新的丙二酸半酯与氯甲酸酯酯化的方法。反应进行混合酸酐，然后自发脱羧。
• METHOD FOR PREPARING QUATERNARY PHOSPHONIUM SALTS
  申请人：Microvast Power Systems Co.,Ltd.

  公开号：US20150166587A1

  公开（公告）日：2015-06-18

  A two-step pathway for preparing high pure quaternary phosphonium salts is disclosed. In the first step, hydrogen phosphide (PH 3 ) or a higher phophine reacts with a protonic compound to produce a phosphonium salt, which then reacts with a carbonic acid diester to produce a quaternary phosphonium salt in the second step. On one hand, hydrogen phosphide (PH 3 ) and higher phophines, including primary phosphines, secondary phosphines, and tertiary phosphines, after neutralization with protonic compound, become sufficiently reactive and can be alkylated by carbonic acid diester to form quaternary phosphonium cations. On the other hand, as an anion-exchange procedure is completely avoided, the process not only gives quaternary phosphonium salts of high purity, but also gives people freedom to design the cation and the anion of a quaternary phosphonium salt synchronously by choosing a preferred phosphine and a protonic compound that can supply a desired anion.

  揭示了一种制备高纯度四元磷铵盐的两步途径。在第一步中，氢磷化物（PH3）或更高的磷化物与质子化合物发生反应，产生磷铵盐，然后在第二步中与碳酸二酯发生反应，产生四元磷铵盐。一方面，氢磷化物（PH3）和更高的磷化物，包括一次磷化物、二次磷化物和三次磷化物，在与质子化合物中和后变得足够活性，可以被碳酸二酯烷基化形成四元磷铵阳离子。另一方面，由于完全避免了阴离子交换程序，该过程不仅提供高纯度的四元磷铵盐，还使人们可以通过选择理想的磷化物和可以提供所需阴离子的质子化合物，同时设计四元磷铵盐的阳离子和阴离子。
• Mixed-blocked polyisocyanates and uses thereof
  申请人：——

  公开号：US20040067318A1

  公开（公告）日：2004-04-08

  Mixed and hybrid blocked polyisocyanates as cross linking agents in coating compositions, having at least one 1,3-dicarbonyl blocking group and at least one thermally active blocking group such that the molar ratio of 1,3-dicarbonyl blocking groups to thermally active blocking groups is in the range of from 4:1 to 1:9, offer improved intercoat adhesion when overcoated and good stability.

  混合和杂化阻化聚异氰酸酯作为涂料组分中的交联剂，具有至少一个1,3-二酮阻化基和至少一个热活性阻化基，使得1,3-二酮阻化基与热活性阻化基的摩尔比在4:1到1:9的范围内，提供了在涂覆上层涂料时改善的层间附着力和良好的稳定性。
• MIXED-BLOCKED POLYISOCYANATES AND USES THEREOF
  申请人：Jones Richard Garfield

  公开号：US20110045191A1

  公开（公告）日：2011-02-24

  Mixed and hybrid blocked polyisocyanates as cross linking agents in coating compositions, having at least one 1,3-dicarbonyl blocking group and at least one thermally active blocking group such that the molar ratio of 1,3-dicarbonyl blocking groups to thermally active blocking groups is in the range of from 4:1 to 1:9, offer improved intercoat adhesion when overcoated and good stability.

  混合和杂化的被阻塞的多异氰酸酯作为涂层组成中的交联剂，至少具有一个1,3-二羰基阻断基和至少一个热活性阻断基，使得1,3-二羰基阻断基与热活性阻断基的摩尔比在4:1至1:9的范围内，提供了改善涂层之间的附着力并具有良好稳定性。
• IMAGE FORMING METHOD
  申请人：GOTOU Hiroshi

  公开号：US20130155145A1

  公开（公告）日：2013-06-20

  An image forming method applying a pretreatment liquid on the surface of a recording medium; and applying an inkjet ink including a colorant, a hydrosoluble organic solvent, a surfactant and water on the surface applied with the pretreatment liquid, wherein the hydrosoluble organic solvent includes at least one polyol including an equilibrium water content in an amount not less than 30% by weight at 23° C. and 80% RH; an amide compound having the following formula (I); and at least one of compounds having the following formulae (II) to (IV), and wherein a pure water transfers to the recording medium in an amount of from 1 to 15 mL/m 2 when measured by a dynamic scanning liquid absorptometer at a contact time of 100 ms.

  一种图像形成方法，其在记录介质的表面上应用预处理液，并在应用预处理液的表面上应用包括颜料、水溶性有机溶剂、表面活性剂和水的喷墨墨水，其中水溶性有机溶剂包括至少一种多元醇，其在23℃和80%相对湿度下的平衡含水量不少于30%（重量百分比），具有以下式（I）的酰胺化合物，以及具有以下式（II）至（IV）之一的化合物，其中在100ms接触时间下，通过动态扫描液体吸收计测量，纯水向记录介质转移的量为1至15 mL/m2。