3-acetoxyphenanthrene | 23414-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-acetoxyphenanthrene
• 英文别名: acetic acid-[3]phenanthryl ester；Essigsaeure-[3]phenanthrylester；Phenanthryl-(3)-acetat；3-Acetoxy-phenanthren；Phenanthrol-(3)-acetat；Phenanthren-3-yl acetate
• CAS: 23414-07-5
• 化学式: C₁₆H₁₂O₂
• 分子量: 236.27
• InChiKey: ALMMSEDNHHFGQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-acetoxyphenanthrene 在 盐酸 、 sodium hydroxide 、 tin 、 alkaline solution 、 硝酸 、 甲烷 、 溶剂黄146 作用下， 生成 3-methoxy-[9]phenanthrylamine
  参考文献：
  名称：

  Studies in the Phenanthrene Series. VII. 3-Hydroxyacetylphenanthrenes and Amino Ketones and Alcohols Derived from Them. Hydroxyaminophenanthrenes¹

  摘要：

  DOI：

  10.1021/ja01323a028
• 作为产物：
  描述：

  3-乙酰基菲 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 生成 3-acetoxyphenanthrene
  参考文献：
  名称：

  致癌性和非致癌性芳烃的K区氧化物反应。与亲核试剂和酸催化反应的比较研究。

  摘要：

  合成了几种致癌和非致癌多环芳烃的 K 区芳烃氧化物，并讨论了它们与各种亲核物的反应活性及其酸催化反应。还讨论了这些化学反应性与致突变性之间的关系。

  DOI：

  10.1248/cpb.26.2014

文献信息

• Straightforward synthesis of phenanthrenes from styrenes and arenes
  作者：Hu Li、Ke-Han He、Jia Liu、Bi-Qin Wang、Ke-Qing Zhao、Ping Hu、Zhang-Jie Shi

  DOI：10.1039/c2cc33100d

  日期：——

  Semi-one-pot synthesis of phenanthrenes from styrenes and arenes was developed through cross-dehydrogenative coupling. A sequence of Heck-type coupling and photo-cyclization were involved and a variety of functionalities were tolerated. This method provides an effective and practical protocol towards the synthesis of substituted phenanthrenes.

  通过交叉脱氢偶合，从苯乙烯和芳烃半一锅合成菲。涉及一系列的Heck型偶联和光环化，并且可以耐受多种功能。该方法为合成取代的菲提供了有效而实用的方案。
• Domino C-H Activation Reactions through Proximity Effects
  作者：Florian Lotz、Klaus Kahle、Mehrnoush Kangani、Soundararasu Senthilkumar、Lutz F. Tietze

  DOI：10.1002/ejoc.201801289

  日期：2018.11.1

  Proximity effects allow C–H‐activation reactions without directing groups in competition with domino‐carbopalladation or Mizoroki–Heck reactions. Vinly–Pd species can be assumed as intermediates, which either react with a double bond or a naphthyl or phenanthryl moiety.

  邻近效应允许C–H-活化反应，而无需指导基团与多米诺卡巴巴拉德反应或Mizoroki-Heck反应竞争。可以认为Vinly-Pd是中间体，可以与双键或萘基或菲基部分反应。
• Studies in the Phenanthrene Series. III. Hydroxy Aldehydes and Hydroxy Ketones¹
  作者：Erich Mosettig、Alfred Burger

  DOI：10.1021/ja01334a062

  日期：1933.7
• Personality disorders and psychoses form two distinct subgroups of homicide among female offenders
  作者：Hanna Putkonen、Jutta Collander、Marja-Liisa Honkasalo、Jouko Lönnqvist

  DOI：10.1080/09585180122116

  日期：2001.1

  This study examined circumstances of homicide by women in relation to their subsequent diagnoses. We investigated the written reports of forensic psychiatric examinations on 125 Finnish women who committed murder, attempted murder, manslaughter, or attempted manslaughter during 1982-92. In 86% of the cases the victims were adults, in 15% children. Intimate partners were the victims in 54% of the cases. Stabbing was the most frequent method and a quarrel the most frequent motive. The diagnoses of personality disorders and psychoses formed distinct subgroups. Psychotic women attacked proportionally more children than the personality disordered, who mainly attacked adults. Personality disordered women were more likely to have been intoxicated with alcohol at the time. Future treatment programmes and studies are suggested.
• Werner, Justus Liebigs Annalen der Chemie, 1902, vol. 322, p. 160
  作者：Werner

  DOI：——

  日期：——