[2',2'-dimethoxyethyl]-2-O-[2'-benzyloxyethyl]-6-O-isopropyl-3,4-di-O-methyl-α-D-mannopyranoside | 647030-26-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2',2'-dimethoxyethyl]-2-O-[2'-benzyloxyethyl]-6-O-isopropyl-3,4-di-O-methyl-α-D-mannopyranoside
• 英文别名: (2S,3S,4S,5R,6R)-2-(2,2-dimethoxyethoxy)-4,5-dimethoxy-3-(2-phenylmethoxyethoxy)-6-(propan-2-yloxymethyl)oxane
• CAS: 647030-26-0
• 化学式: C₂₄H₄₀O₉
• 分子量: 472.576
• InChiKey: GOYZIKLKGKTQQY-AZKGINQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  33
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [2',2'-dimethoxyethyl]-2-O-[2'-benzyloxyethyl]-6-O-isopropyl-3,4-di-O-methyl-α-D-mannopyranoside 在 盐酸 、 sodium chlorite 、 disodium hydrogenphosphate 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 反应 4.0h， 生成 [(2S,3S,4S,5R,6R)-3-(2-Benzyloxy-ethoxy)-6-isopropoxymethyl-4,5-dimethoxy-tetrahydro-pyran-2-yloxy]-acetic acid
  参考文献：
  名称：

  Synthesis and Structure−Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1

  摘要：

  As part of our ongoing research in the development of alpha4beta7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the display of essential side chains in a suitable binding conformation while eliminating backbone amide bonds and therefore improving pharmacokinetic parameters of the drug. Except for a few examples, peptidomimetics scaffolds have only been moderately successful and often yield molecules that lack the potency of their peptide counterparts. However, we present herein a successful application of using a rigid scaffold. Starting from a mannopyranoside analogue previously discovered in our laboratory as an inhibitor of the alpha4beta1/vascular cell adhesion molecule interaction, a biased library of functionalized carbohydrates was developed. One compound emerged from this library as an active and selective antagonist toward the alpha4beta7/mucosal addressin cell adhesion molecule interaction. Conformational. implications and the relevance of different pharmacophoric patterns will be discussed in order to explain the reverse selectivity and enhanced affinity.

  DOI：

  10.1021/jm020487h
• 作为产物：
  描述：

  在 palladium on activated charcoal 氢氧化钾 、 氢气 作用下， 以 甲醇 、 水 、 二甲基亚砜 为溶剂， 反应 1.0h， 生成 [2',2'-dimethoxyethyl]-2-O-[2'-benzyloxyethyl]-6-O-isopropyl-3,4-di-O-methyl-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis and Structure−Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1

  摘要：

  As part of our ongoing research in the development of alpha4beta7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the display of essential side chains in a suitable binding conformation while eliminating backbone amide bonds and therefore improving pharmacokinetic parameters of the drug. Except for a few examples, peptidomimetics scaffolds have only been moderately successful and often yield molecules that lack the potency of their peptide counterparts. However, we present herein a successful application of using a rigid scaffold. Starting from a mannopyranoside analogue previously discovered in our laboratory as an inhibitor of the alpha4beta1/vascular cell adhesion molecule interaction, a biased library of functionalized carbohydrates was developed. One compound emerged from this library as an active and selective antagonist toward the alpha4beta7/mucosal addressin cell adhesion molecule interaction. Conformational. implications and the relevance of different pharmacophoric patterns will be discussed in order to explain the reverse selectivity and enhanced affinity.

  DOI：

  10.1021/jm020487h

文献信息

• Synthesis and Structure−Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1
  作者：Elsa Locardi、Jürgen Boer、Armin Modlinger、Anja Schuster、Bernhard Holzmann、Horst Kessler

  DOI：10.1021/jm020487h

  日期：2003.12.1

  As part of our ongoing research in the development of alpha4beta7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the display of essential side chains in a suitable binding conformation while eliminating backbone amide bonds and therefore improving pharmacokinetic parameters of the drug. Except for a few examples, peptidomimetics scaffolds have only been moderately successful and often yield molecules that lack the potency of their peptide counterparts. However, we present herein a successful application of using a rigid scaffold. Starting from a mannopyranoside analogue previously discovered in our laboratory as an inhibitor of the alpha4beta1/vascular cell adhesion molecule interaction, a biased library of functionalized carbohydrates was developed. One compound emerged from this library as an active and selective antagonist toward the alpha4beta7/mucosal addressin cell adhesion molecule interaction. Conformational. implications and the relevance of different pharmacophoric patterns will be discussed in order to explain the reverse selectivity and enhanced affinity.