甲基磺草酮 | 104206-82-8

• 物质功能分类: 化学农药原药 - 除草剂 - 其他除草剂
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲基磺草酮
• 中文别名: 硝磺草酮；2-(4-甲磺酰基-2-硝基苯甲酰基)环己烷-1,3-二酮；2-(2-硝基－4-甲磺酰基苯加酰)环己烷-1,3-二酮；2-(4-甲磺酰基-2-硝基苯甲酰基)环已烷-1,3-二酮；2-[4-(甲基磺酰)-2-硝基苯]-1,3-环己胺酮
• 英文名称: mesotrione
• 英文别名: 2-(4-(methylsulfonyl)-2-nitrobenzoyl)cyclohexane-1,3-dione；2-(4-mesyl-2-nitrobenzoyl)cyclohexane-1,3-dione；2-(4-methanesulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione；2-(2-nitro-4-methylsulfonylbenzoyl)cyclohexane-1,3-dione；2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione；2-[2-nitro-4-(methylsulphonyl)benzoyl]-1,3-cyclohexanedione；2-(2-nitro-4-methanesulfonylbenzoyl)cyclohexane-1,3-dione；2-(4-methanesulfonyl-2-nitrobenzoyl)-1,3-cyclohexanedione；2-(4-methylsulphonyl-2-nitrobenzoyl)-1,3-cyclohexanedione；2-(4-mesyl-2-nitrobenzoyl)-1,3-cyclohexanedione；2-(4-methylsulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione
• CAS: 104206-82-8
• 化学式: C₁₄H₁₃NO₇S
• mdl: MFCD04112617
• 分子量: 339.326
• InChiKey: KPUREKXXPHOJQT-UHFFFAOYSA-N

物化性质

• 熔点：
  165°
• 沸点：
  643.3±55.0 °C(Predicted)
• 密度：
  1.474±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿（微溶）、甲醇（微溶、加热）
• LogP：
  -0.700 (est)
• 颜色/状态：
  Pale yellow solid
• 气味：
  Faint pleasant odor
• 蒸汽压力：
  <5.69X10-3 mPa /<4.27X10-8 mm Hg)/ at 20 °C
• 稳定性/保质期：
  Stable to hydrolysis (pH 4-9).
• 解离常数：
  pKa = 3.12 at 20 °C; 0.6503 (associated) and 0.3404 (dissociated)
• 碰撞截面：
  175.66 Ų [M+H]+ [CCS Type: TW]

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.357
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

代谢

有限的代谢，多达5%通过羟基化代谢。

Limited metabolism, up to 5% metabolized by hydroxylation.

来源:Hazardous Substances Data Bank (HSDB)

代谢

[(14)C]-2-(4-甲基磺酰基-2-硝基苯甲酰基)-1,3-环己二酮（甲氧咪草烟）在雄性和雌性大鼠和小鼠单次口服剂量为1或100毫克/千克后的代谢命运已经确定，在大鼠连续14次口服1毫克/千克的剂量后，以及在手术准备好的、胆管插管的大鼠单次口服50毫克/千克的剂量后。...甲氧咪草烟在大鼠和小鼠中都被广泛吸收并迅速通过尿液排出。...主要的代谢途径是芳香环的羟基化。

The metabolic fate of [(14)C]-2-(4-methylsulphonyl-2-nitrobenzoyl)-1,3-cyclohexanedione (mesotrione) has been determined in the male and female rat and mouse following a single oral dose of either 1 or 100 mg/kg, in rat given 14 consecutive oral doses of 1 mg/kg, and in the surgically prepared, bile duct-cannulated rat following a single oral dose of 50 mg/kg. ...Mesotrione was extensively absorbed and rapidly excreted via urine in both rat and mouse. ...The major metabolic pathway was hydroxylation of the aromatic ring.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

识别和使用：异恶草酮是一种淡黄色固体，具有轻微的愉快气味。异恶草酮是一种除草剂，用于田间的玉米、种子玉米、甜玉米、黄色爆米花和高粱。在美国注册使用，但批准的农药用途可能会定期更改，因此必须咨询联邦、州和地方当局以获取当前批准的用途。人类暴露和毒性：关于人类接触异恶草酮的影响的信息有限。给志愿者服用异恶草酮后，血浆中的酪氨酸浓度增加，在每千克体重4毫克的剂量下，血浆酪氨酸浓度达到大约300纳米摩尔/毫升的最大值。浓度在给药后2天内恢复到背景水平。在服用4毫克/千克的剂量后的24小时内，尿液中酪氨酸代谢物的排泄增加，但在接下来的24小时期间恢复到背景水平。因此，异恶草酮的最小和短暂效应最小化了在职业使用过程中发生系统暴露时产生临床效应的可能性。异恶草酮不太可能对人类致癌。动物研究：在动物中，异恶草酮是一种轻微的眼部刺激物，但不是皮肤刺激物或皮肤致敏物。在亚慢性 and 慢性 口服研究中，大鼠、小鼠和狗的主要不良影响包括眼部病变、肝脏和肾脏影响以及/或体重下降。在慢性研究和繁殖研究中，大鼠、小鼠和狗的血浆酪氨酸水平升高。认为眼部、肝脏和肾脏的影响是由血液中酪氨酸水平升高引起的，这是由于抑制了4-羟基苯基丙酮酸双加氧酶酶。在急性亚慢性神经毒性研究中，没有发现大鼠的神经病理学证据。然而，慢性大鼠研究中坐骨神经脱髓鞘与血浆酪氨酸浓度增加有关。在2年大鼠研究中，仅在最高剂量水平下的雌性大鼠中甲状腺腺瘤的发生率增加，这也与血浆酪氨酸浓度增加有关。在大鼠、兔和小鼠发育研究中，观察到骨骼矿化减少/延迟，而在母体毒性不明显的情况下。生态毒性研究：检查了抗氧化应激系统、脂质膜的饱和度变化以及细菌降解异恶草酮的能力。结果显示，大肠杆菌DH5-α能够耐受高剂量的除草剂（田间速率的10倍），并在暴露3小时后完全降解异恶草酮。在降解期之前，存在异恶草酮的生长率低于对照组，显示出这种除草剂对细菌细胞的毒性作用。膜脂质饱和度的变化减少了活性氧物种造成的损害，并可能阻碍了外源化合物进入细胞，同时激活了谷胱甘肽-S-转移酶酶。

IDENTIFICATION AND USE: Mesotrione is a pale yellow solid with a faint pleasant odor. Mesotrione is an herbicide used on field corn, seed corn, sweet corn, yellow popcorn, and grain sorghum. Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: Limited information is available on the effects of exposure to mesotrione on humans. Administration of mesotrione to volunteers resulted in an increase in plasma tyrosine concentrations, which reached a maximum of approximately 300 nmol/mL following a dose of 4 mg/kg body weight. Concentrations returned to background levels within 2 days of dosing. Urinary excretion of tyrosine metabolites was increased during the 24 hr immediately following a dose of 4 mg/kg, but returned to background levels during the following 24 hr period. Thus, the minimal and transient effects of mesotrione minimize the likelihood of a clinical effect in the event of systemic exposure occurring during occupational use. Mesotrione is not likely to be carcinogenic to humans. ANIMAL STUDIES: In animals, mesotrione is a mild eye irritant, but is not a dermal irritant or a dermal sensitizer. In subchronic and chronic oral studies, ocular lesions, liver and kidney effects, and/or body weight decrements were the major adverse effects seen in rat, mouse, and dog. Plasma tyrosine levels were increased in rat, mouse and dog in the chronic and reproduction studies. The ocular, liver and kidney effects are believed to be mediated by high tyrosine levels in the blood caused by inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase. No evidence of neuropathology was found in acute and sub-chronic neurotoxicity studies in rat. However, sciatic nerve demyelination in the chronic rat study was associated with increased plasma tyrosine concentration. Increased incidence of thyroid adenomas in female rats only at the highest dose level in the 2 year rat study was also associated with increased plasma tyrosine concentration. Reduced/delayed ossification in rat, rabbit and mouse developmental studies were noted in the absence of overt maternal toxicity. ECOTOXICITY STUDIES: Antioxidative stress systems, saturation changes of lipid membranes, and the capacity of bacteria to degrade mesotrione were examined. The results showed that Escherichia coli DH5-alpha was able to tolerate high doses of the herbicide (10 times field rate), and completely degraded mesotrione after 3 hr of exposure. Growth rates in the presence of mesotrione were lower than in the control, prior to the period of degradation, showing toxic effects of this herbicide on bacterial cells. Changes in the saturation of the membrane lipids reduced the damage caused by reactive oxygen species and possibly hindered the entry of xenobiotics in the cell, while activating glutathione-S-transferase enzyme.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：不太可能对人类致癌

Cancer Classification: Not Likely to be Carcinogenic to Humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

大鼠LC50 > 5000毫克/立方米

LC50 (rat) > 5,000 mg/m3

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

在大鼠中进行了一系列急性和亚慢性以及生殖研究，涉及不同剂量的硝磺草酮给药，有时伴随饮食中的L-酪氨酸共同给药，以及在兔中使用硝磺草酮和酪氨酸进行发育研究，以阐明酪氨酸在效应发生中的作用。变化的发生率和/或严重程度与血浆酪氨酸浓度相关，但与硝磺草酮的浓度无关。

... A range of acute, subchronic and reproduction studies in the rat involving administration of different doses of mesotrione, with or without co-administration of dietary L-tyrosine and a developmental study in the rabbit utilising both mesotrione and tyrosine were used to elucidate the role of tyrosine in the pathogenesis of effects. ...The incidence and/or severity of the changes correlated with plasma tyrosine concentrations but not with concentrations of mesotrione.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大约70%的/mestrione在72小时内被吸收。/Mestrione在体内广泛分布，72小时内在肝脏和肾脏的残留量最高。没有累积的证据。65-70%在72小时内排出，主要是通过尿液（55%）。

Approximately 70% /mestrione was absorbed/ within 72 hours. /Mestrione was/ widely distributed, highest residues in liver and kidney at 72 hours. No evidence of accumulation. 65-70% excreted within 72 hours, mainly via urine (55%)

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

NTBC（2-(2-硝基-4-氟甲基苯甲酰)-1,3-环己二酮）和硝磺草酮（2-(4-甲磺酰基-2-硝基苯甲酰)-1,3-环己二酮）是4-羟基苯基丙酮酸双加氧酶（HPPD）的抑制剂。NTBC已成功用作治疗遗传性酪氨酸血症1型（HT-1），而硝磺草酮已开发为除草剂。在健康男性志愿者单次口服给药后，研究了这两种化合物的药代动力学。NTBC研究旨在评估两种不同制剂的生物等效性，并确定诱导的酪氨酸血症的程度。硝磺草酮研究是为了确定对酪氨酸分解代谢的影响的大小和持续时间。此外，还测量了未改变的硝磺草酮的尿排泄，以评估这一清除途径的重要性，并帮助制定监测职业暴露的策略。总共28名志愿者参加了两项单独的研究。在第一项研究中，比较了液体制剂和胶囊制剂中NTBC的相对生物利用度，并测量了对血浆酪氨酸浓度的影响。在第二项研究中确定了硝磺草酮在三个剂量下的药代动力学。监测了血浆酪氨酸浓度，并测量了硝磺草酮和酪氨酸代谢物的尿排泄。在所研究的剂量水平上，两种化合物均能很好地耐受。在单次口服1 mg/kg体重任一制剂后，NTBC的血浆峰浓度迅速达到，血浆半衰期约为54小时。平均（±标准差）AUC(0,∞)（胶囊602±154 vs溶液602±146微克×毫升-1×小时）或t1/2（胶囊55±13 vs溶液54±8小时）没有统计学差异，这些参数支持两种制剂的生物等效性。硝磺草酮也迅速吸收，尿液中以原形排除了大量剂量。血浆半衰期约为1小时，与剂量无关，AUC(0,∞)和Cmax随剂量线性增加。在任一制剂中给予1 mg NTBC/kg后，血浆中酪氨酸的浓度增加到大约1100纳米摩尔/毫升。浓度在给药后14天仍约为背景的8倍，但在第二次给药后2个月内已恢复到背景水平。给予硝磺草酮后，酪氨酸浓度增加，在给予4 mg/kg体重后达到最大值，约为300纳米摩尔/毫升。浓度在给药后2天内恢复到背景水平。在给予4 mg硝磺草酮/kg后的24小时内，酪氨酸代谢物的尿排泄增加，但在随后的24小时期间恢复到背景水平。

NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione (2-(4-methylsulphonyl-2-nitrobenzoyl)-1,3-cyclohexanedione) are inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD). NTBC has been successfully used as a treatment for hereditary tyrosinaemia type 1 (HT-1), while mesotrione has been developed as an herbicide. The pharmacokinetics of the two compounds were investigated in healthy male volunteers following single oral administration. The aim of the NTBC study was to assess the bioequivalence of two different formulations and to determine the extent of the induced tyrosinaemia. The mesotrione study was performed to determine the magnitude and duration of the effect on tyrosine catabolism. Additionally, the urinary excretion of unchanged mesotrione was measured to assess the importance of this route of clearance and to help develop a strategy for monitoring occupational exposure. ... A total of 28 volunteers participated in two separate studies with the compounds. In the first study, the relative bioavailability of NTBC from liquid and capsule formulations was compared and the effect on plasma tyrosine concentrations measured. In the second study the pharmacokinetics of mesotrione were determined at three doses. Plasma tyrosine concentrations were monitored and the urinary excretion of mesotrione and tyrosine metabolites was measured. Both compounds were well tolerated at the dose levels studied. Peak plasma concentrations of NTBC were rapidly attained following a single oral dose of 1 mg x kg(-1) body weight of either formulation and the half-life in plasma was approximately 54 hr. There were no statistical differences in mean (+/- s.d.) AUC(0,infinity) (capsule 602 +/- 154 vs solution 602 +/- 146 ug x ml(-1) hr) or t1/2 (capsule 55 +/- 13 vs solution 54 +/- 8 hr) and these parameters supported the bioequivalence of the two formulations. Mesotrione was also rapidly absorbed, with a significant proportion of the dose eliminated unchanged in urine. The plasma half-life was approximately 1 hr and was independent of dose and AUC(0,infinity) and Cmax increased linearly with dose. Following administration of 1 mg NTBC x kg(-1) in either formulation, the concentrations of tyrosine in plasma increased to approximately 1100 nmol x ml(-1). Concentrations were still approximately 8 times those of background at 14 days after dosing, but had returned to background levels within 2 months of the second dose. Administration of mesotrione resulted in an increase in tyrosine concentrations which reached a maximum of approximately 300 nmol x ml(-1) following a dose of 4 mg x kg(-1) body weight. Concentrations returned to those of background within 2 days of dosing. Urinary excretion of tyrosine metabolites was increased during the 24 hr immediately following a dose of 4 mg mesotrione x kg(-1), but returned to background levels during the following 24 hr period. ...

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  N
• 安全说明：
  S60,S61
• 危险类别码：
  R50/53
• WGK Germany：
  2
• 危险品运输编号：
  UN 3077
• 海关编码：
  2914700090
• 储存条件：
  0-6°C

制备方法与用途

甲基磺草酮是一种选择性除草剂，用于玉米田中防除一年生阔叶杂草和某些禾本科杂草。以下是关于甲基磺草酮的详细信息：

制备与使用

• 制备方法：通过特定化学反应合成，通常包括多个步骤。
• 包装形式：一般以浓缩乳油或悬浮剂等形式提供。

主要特点

1. 作用机理: 作为HPPD（4-羟苯基丙酮酸双氧化酶）抑制剂，阻止杂草中尿黑酸生物合成的中间过程。这导致植株无法产生必要的色素和生育酚。
2. 选择性：对玉米等作物具有较好的耐受性。
3. 传导性: 可在植物体内上下传导。

应用方法

• 芽前处理：

  • 土壤表面喷洒，用量为200～300g/hm²。
  • 建议与甲酯化植物油混合作用于干旱气候区，如70～80g/hm² +1%甲酯化植物油。

• 苗后茎叶处理：

  • 叶片喷洒，用量为100～150g/hm²。
  • 适用于不同类型的玉米田，北方地区建议在干旱条件下使用。

混用情况

• 芽前可与莠去津、乙草胺、异丙草胺等混用；
• 苗后茎叶处理可与烟嘧磺隆（玉农乐）、砜嘧磺隆(rimsuluron) 等混合施用，增强防除效果。

应用范围

广泛应用于以下作物田中：

• 玉米：芽前或芽后的阔叶杂草和禾本科杂草防治。
• 稗、马唐、狗尾草、臂形草等部分禾本科杂草。

重要注意事项

1. 需按照说明书正确施用，遵循推荐的剂量及方法；
2. 注意环境安全性和使用者防护措施；
3. 尽量减少对非靶标生物的影响。

通过上述信息可知，甲基磺草酮在玉米田中具有良好的防除效果和较高的选择性。但在使用过程中需要注意环境保护与操作规范，以确保农业生产的可持续发展。

反应信息

• 作为反应物：
  描述：

  甲基磺草酮 以 水 为溶剂， 生成 2-氨基-4-(甲基磺酰基)苯甲酸
  参考文献：
  名称：

  Cu II离子存在下三酮类除草剂甲基磺草酮的光降解

  摘要：

  该研究首先关注Cu II离子与甲基磺草酮的络合。实验吸收光谱结合量子化学计算结果表明，Cu II离子以O1和O7原子之间的双齿模式与分子结合。计算出的配合物的电子跃迁表明，它们中的三个主要是配体到配体的电子转移，而能量最低的一个涉及配体到金属的电荷转移（LMCT）。这项工作的第二个目的是探索Cu II的作用络合对甲基磺草酮的光降解。根据实验结果提出了反应的动力学和机理。研究了不同参数的影响，例如辐射波长，混合物的氧气浓度和pH值，以及反应性物质（例如羟基）的产生。甲基磺草酮在水中的光化学降解源自分子的三重激发态，并导致光水解过程。对于该配合物，主要通过在其LMCT吸收带中激发，铜和甲基磺草酮之间可能发生电子转移，并且甲基磺草酮-Cu II的机理光降解不同：除了光水解途径外，还发生光环化过程，配体的氧化伴随Cu II离子的还原。

  DOI：

  10.1016/j.jphotochem.2015.09.010
• 作为产物：
  描述：

  2-硝基-4-甲砜基氯苯 在 氯化亚砜 、 benzyl triethylammonium azide 、 三乙胺 、 sodium hydroxide 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 3.0h， 生成 甲基磺草酮
  参考文献：
  名称：

  一种三酮类化合物及其中间体的制备方法

  摘要：

  本发明公开了一种三酮类化合物及其中间体的制备方法。该方法包括：以化合物（I）为原料，在碱的作用下，与化合物（II）发生亲核取代反应，再经氧化反应得到化合物（III），化合物（III）再经酰氯化，酯化，重排，得到三酮类目标产物。本发明的有益效果主要体现在：反应条件温和，工艺简单，收率高，产品质量好，并且生产成本低，三废少，利于工业化生产。

  公开号：

  CN105712912B

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] 3-[(HYDRAZONO)METHYL]-N-(TETRAZOL-5-YL)-BENZAMIDE AND 3-[(HYDRAZONO)METHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE DERIVATIVES AS HERBICIDES<br/>[FR] DÉRIVÉS DE 3-[(HYDRAZONO))MÉTHYL]-N-(TÉTRAZOL-5-YL)-BENZAMIDE ET DE 3-[(HYDRAZONO)MÉTHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE UTILISÉS EN TANT QU'HERBICIDES
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：WO2021013969A1

  公开（公告）日：2021-01-28

  The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4, R5 and R6 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of compounds of Formula (I) as a herbicide.

  本发明涉及以下式（I）的化合物或其农业上可接受的盐，其中Q、R2、R3、R4、R5和R6如本文所述。该发明还涉及包含所述化合物的组合物，使用这些组合物控制杂草的方法，以及将式（I）的化合物用作除草剂的用途。
• [EN] SUBSTITUTED QUINAZOLINES AS FUNGICIDES<br/>[FR] QUINAZOLINES SUBSTITUÉES, UTILISÉES EN TANT QUE FONGICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2010136475A1

  公开（公告）日：2010-12-02

  The present invention relates to a compound of formula (I) wherein wherein the substituents have the definitions as defined in claim 1or a salt or a N-oxide thereof, their use and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

  本发明涉及一种具有如下式（I）的化合物，其中取代基具有权利要求1中定义的定义，或其盐或N-氧化物，它们的用途以及用于控制和/或预防植物中微生物感染，特别是真菌感染的方法，以及制备这些化合物的方法。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• [EN] HERBICIDALLY ACTIVE HETEROARYL-S?BSTIT?TED CYCLIC DIONES OR DERIVATIVES THEREOF<br/>[FR] DIONES CYCLIQUES SUBSTITUÉES PAR HÉTÉROARYLE À ACTIVITÉ HERBICIDE OU DÉRIVÉS DE CELLES-CI
  申请人：SYNGENTA LTD

  公开号：WO2011012862A1

  公开（公告）日：2011-02-03

  The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.

  该发明涉及一种化合物，其化学式为(I)，适用作为除草剂，其中G为氢或农业可接受的金属、磺酸盐、铵盐或潜伏基团；Q为未取代或取代的含有至少一个来自O、N和S的杂原子的饱和或单不饱和的C3-C8杂环烷基，或Q为杂芳基或取代的杂芳基；m为1、2或3；Het为可选择地取代的单环或双环杂芳环；且该化合物可选择地为其农学上可接受的盐。