N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide | 247226-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide
• 英文别名: N-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)acetamide
• CAS: 247226-17-1
• 化学式: C₁₁H₁₉NO₃
• 分子量: 213.277
• InChiKey: BIAQDHAKKCFALJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide 生成
  参考文献：
  名称：

  Bioorg. Med. Chem. Lett. 2001, 11, 2377-2380

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-N-acetyl-3-aminopropane-1,2-diol 、 环己酮 在 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 24.0h， 以66%的产率得到N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide
  参考文献：
  名称：

  Synthesis of Biologically Important Guanidine-Containing Molecules Using Triflyl-Diurethane Protected Guanidines

  摘要：

  DOI：

  10.1055/s-1999-3653

文献信息

• Synthesis of Biologically Important Guanidine-Containing Molecules Using Triflyl-Diurethane Protected Guanidines
  作者：Tracy J. Baker

  DOI：10.1055/s-1999-3653

  日期：1999.8
• N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors
  作者：Ming Xian、Xiaopeng Li、Xiaoping Tang、Xinchao Chen、Zhongling Zheng、James J Galligan、David L Kreulen、Peng G Wang

  DOI：10.1016/s0960-894x(01)00456-5

  日期：2001.9

  Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this guanethidine together with their N-hydroxyl derivatives were report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited Weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability tinder the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Bioorg. Med. Chem. Lett. 2001, 11, 2377-2380
  作者：

  DOI：——

  日期：——