{(R)-1-[(1R,3R,3aR,7R,7aR)-7-Isopropyl-4-methyl-3-(2-methyl-allyl)-1,3,3a,6,7,7a-hexahydro-isobenzofuran-1-yl]-1-methyl-pent-4-enyloxy}-trimethyl-silane | 201209-76-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: {(R)-1-[(1R,3R,3aR,7R,7aR)-7-Isopropyl-4-methyl-3-(2-methyl-allyl)-1,3,3a,6,7,7a-hexahydro-isobenzofuran-1-yl]-1-methyl-pent-4-enyloxy}-trimethyl-silane
• 英文别名: [(2R)-2-[(1R,3R,3aR,7R,7aR)-4-methyl-3-(2-methylprop-2-enyl)-7-propan-2-yl-1,3,3a,6,7,7a-hexahydro-2-benzofuran-1-yl]hex-5-en-2-yl]oxy-trimethylsilane
• CAS: 201209-76-9
• 化学式: C₂₅H₄₄O₂Si
• 分子量: 404.709
• InChiKey: HYFWDGUMQXHFFN-VRVGQERDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.15
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  {(R)-1-[(1R,3R,3aR,7R,7aR)-7-Isopropyl-4-methyl-3-(2-methyl-allyl)-1,3,3a,6,7,7a-hexahydro-isobenzofuran-1-yl]-1-methyl-pent-4-enyloxy}-trimethyl-silane 在 bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum 、 四丁基氟化铵 作用下， 以 氘代苯 为溶剂， 反应 48.0h， 生成 (Z)-(1R,2R,6R,7R,8R,9R)-6-Isopropyl-3,9,12-trimethyl-14-oxa-tricyclo[6.5.1.0^2,7]tetradeca-3,11-dien-9-ol
  参考文献：
  名称：

  An unexpected product arising from metal alkylidene mediated ring-closing diene metathesis

  摘要：

  Ring-closing diene metathesis of siloxytriene 3 surprisingly afforded siloxytricycle 9 in which the newly formed ring is one carbon unit smaller than expected. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10373-2
• 作为产物：
  描述：

  (1R,3R,3aR,7R,7aR)-3(R)-(7-isopropyl-4-methyl-3-prop-2-ynyl-1,3,3a,6,7,7a-hexahydroisobenzofuran-1-yl)-butane-1,3-diol 在 二氯二茂锆 、 三氟化硼乙醚 、 碘 、 乙烯基-锂 、 三苯基膦 作用下， 生成 {(R)-1-[(1R,3R,3aR,7R,7aR)-7-Isopropyl-4-methyl-3-(2-methyl-allyl)-1,3,3a,6,7,7a-hexahydro-isobenzofuran-1-yl]-1-methyl-pent-4-enyloxy}-trimethyl-silane
  参考文献：
  名称：

  An unexpected product arising from metal alkylidene mediated ring-closing diene metathesis

  摘要：

  Ring-closing diene metathesis of siloxytriene 3 surprisingly afforded siloxytricycle 9 in which the newly formed ring is one carbon unit smaller than expected. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10373-2

文献信息

• An unexpected product arising from metal alkylidene mediated ring-closing diene metathesis
  作者：Daisy Joe、Larry E. Overman

  DOI：10.1016/s0040-4039(97)10373-2

  日期：1997.12

  Ring-closing diene metathesis of siloxytriene 3 surprisingly afforded siloxytricycle 9 in which the newly formed ring is one carbon unit smaller than expected. (C) 1997 Elsevier Science Ltd.