(trans,6R,7R,10R,11S) ethyl 6-hydroxy-11-(methoxymethoxy)-7,10-oxidotricosa-2,3-enoate | 248601-77-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (trans,6R,7R,10R,11S) ethyl 6-hydroxy-11-(methoxymethoxy)-7,10-oxidotricosa-2,3-enoate
• 英文别名: ethyl (E,6R)-6-hydroxy-6-[(2R,5R)-5-[(1S)-1-(methoxymethoxy)tridecyl]oxolan-2-yl]hex-2-enoate
• CAS: 248601-77-6
• 化学式: C₂₇H₅₀O₆
• 分子量: 470.69
• InChiKey: MDBAJTAKRSLLGG-FIBKVTAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  33
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (trans,6R,7R,10R,11S) ethyl 6-hydroxy-11-(methoxymethoxy)-7,10-oxidotricosa-2,3-enoate 在 titanium(IV) isopropylate 、 4-二甲氨基吡啶 、 正丁基锂 、 4 A molecular sieve 、 二异丁基氢化铝 、 potassium carbonate 、 对甲苯磺酸 、 (+)-Weinsaeure-diethylester 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 40.5h， 生成 (6R,7R,10R,11R,14R,15S)-1-tert-butyldiphenylsilyloxy-15-(methoxymethoxy)-7,10:11,14-bisoxidoheptacos-3-yn-6-ol
  参考文献：
  名称：

  Total Synthesis of Squamotacin

  摘要：

  The first total synthesis of (+)-squamotacin, 1, which has shown cytotoxic selectivity for the human prostate tumor cell line, was; achieved in 27 steps and 0.83% yield starting with (+)-muricatacin, 4. All asymmetric centers in the bistetrahydrofuran fragment of the molecules were produced by the Sharpless asymmetric dihydroxylation (AD) and the asymmetric epoxidation (AE) reactions.

  DOI：

  10.1021/jo990599p
• 作为产物：
  描述：

  (4R,5R,8R,9S) 5,8-oxidoheneicosa-9-hydroxy-1,4-olide 在 二异丁基氢化铝 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 33.0h， 生成 (trans,6R,7R,10R,11S) ethyl 6-hydroxy-11-(methoxymethoxy)-7,10-oxidotricosa-2,3-enoate
  参考文献：
  名称：

  Total Synthesis of Squamotacin

  摘要：

  The first total synthesis of (+)-squamotacin, 1, which has shown cytotoxic selectivity for the human prostate tumor cell line, was; achieved in 27 steps and 0.83% yield starting with (+)-muricatacin, 4. All asymmetric centers in the bistetrahydrofuran fragment of the molecules were produced by the Sharpless asymmetric dihydroxylation (AD) and the asymmetric epoxidation (AE) reactions.

  DOI：

  10.1021/jo990599p

文献信息

• Total Synthesis of Squamotacin
  作者：Santosh C. Sinha、Subhash C. Sinha,* and、Ehud Keinan

  DOI：10.1021/jo990599p

  日期：1999.9.1

  The first total synthesis of (+)-squamotacin, 1, which has shown cytotoxic selectivity for the human prostate tumor cell line, was; achieved in 27 steps and 0.83% yield starting with (+)-muricatacin, 4. All asymmetric centers in the bistetrahydrofuran fragment of the molecules were produced by the Sharpless asymmetric dihydroxylation (AD) and the asymmetric epoxidation (AE) reactions.