Methyl 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]prop-2-enoate | 412269-14-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Methyl 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]prop-2-enoate
• 英文别名: methyl 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]prop-2-enoate
• CAS: 412269-14-8
• 化学式: C₁₆H₁₄ClNO₄S
• 分子量: 351.81
• InChiKey: HWDUZTHOUGQCCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]prop-2-enoate 在 草酰氯 、 羟胺 、 碳酸氢钠 、 N,N-二甲基甲酰胺 、 sodium hydroxide 作用下， 生成 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]-N-hydroxyprop-2-enamide
  参考文献：
  名称：

  Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

  摘要：

  A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC50 of 34 nM. These results identify lead compounds with potential for the development of a novel class of trypanocidal agent. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.072
• 作为产物：
  描述：

  methyl 3-[3-(chlorosulfonyl)phenyl]acrylate 、 对氯苯胺 生成 Methyl 3-[3-[(4-chlorophenyl)sulfamoyl]phenyl]prop-2-enoate
  参考文献：
  名称：

  Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

  摘要：

  A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC50 of 34 nM. These results identify lead compounds with potential for the development of a novel class of trypanocidal agent. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.072

文献信息

• Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei
  作者：John M. Kelly、Martin C. Taylor、David Horn、Einars Loza、Ivars Kalvinsh、Fredrik Björkling

  DOI：10.1016/j.bmcl.2012.01.072

  日期：2012.3

  A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC50 of 34 nM. These results identify lead compounds with potential for the development of a novel class of trypanocidal agent. (c) 2012 Elsevier Ltd. All rights reserved.