毒理性
◉ 母乳喂养期间使用总结：去铁胺口服吸收不良，因此不太可能进入婴儿的血液循环或对母乳喂养的婴儿产生任何不良影响。有限的信息表明，母亲每天服用高达2克去铁胺不会影响母乳中的铁含量，并且在对两名母乳喂养的婴儿的研究中没有发现任何不良影响。一些专家主张对因β-地中海贫血引起铁过载的妇女进行母乳喂养。然而，由于关于去铁胺在哺乳期间使用的已发表信息很少，建议监测婴儿的血清铁水平。
◉ 对母乳喂养婴儿的影响：一名患有β-地中海贫血的妇女在分娩后3天重新开始每周5天、每次2克去铁胺的皮下注射。她从出生时起就母乳喂养了她的双胞胎之一（喂养程度未说明）。在母乳喂养17天后，婴儿的血清水平如下：铁17.4微摩尔/升，铁蛋白200微克/升，转铁蛋白16.8微摩尔/升，均在正常范围内。血清尿素、钙和镁也是正常的。第二个双胞胎因住院时间较长，医院内的母乳喂养状况未报告。两个婴儿在产后4个月期间都进行了母乳喂养（喂养程度未说明）。4个月时，两个婴儿的神经和运动发育都正常，实验室值与他们的杂合子β-地中海贫血相符：胎儿血红蛋白F 11.1%和8.4%，血红蛋白10.5克/升和10.5克/升，网织红细胞3.3%和2.6%，平均红细胞体积60 fL和58 fL。他们的血清铁、铁蛋白、转铁蛋白、肝酶、血浆尿素和胆红素水平都是正常的。
一名患有β-地中海贫血的妇女通过剖宫产生下一名婴儿，并在接受去铁胺（剂量未说明）的同时从出生起就母乳喂养她的婴儿。她的婴儿没有报告任何不良影响。
◉ 对泌乳和母乳的影响：截至修订日期，未找到相关的已发表信息。
◉ Summary of Use during Lactation:Deferoxamine is poorly absorbed orally, so it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Limited information indicates that maternal doses of deferoxamine up to 2 grams daily do not affect iron levels in breastmilk and did not cause any adverse effects in two breastfed infants. Some experts advocate breastfeeding in women receiving deferoxamine for iron overload caused by beta-thalassemia. However, since little published information is available on the use of deferoxamine during breastfeeding, monitoring of the infant's serum iron is recommended.
◉ Effects in Breastfed Infants:A woman with beta-thalassemia restarted deferoxamine 2 grams subcutaneously 5 days per week 3 days after delivery. She breastfed (extent not stated) one of her twins from birth. After 17 days of breastfeeding, the infant's serum levels were as follows: iron 17.4 micromoles/L, ferritin 200 mcg/L, and transferrin16.8 micromoles/L, all in the normal range. Serum urea, calcium and magnesium were also normal. The second twin was hospitalized for longer and breastfeeding status in the hospital was not reported. Both infants were breastfed (extent not stated) for 4 months postpartum. Both had normal neurologic and motor development at 4 months and laboratory values consistent with their heterozygous beta-thalassemia: hemoglobin F 11.1% and 8.4%, hemoglobin 10.5 g/L and 10.5 g/L, reticulocytes 3.3% and 2.6%, and median erythrocyte volume 60 fL and 58 fL. Their serum levels of iron, ferritin, transferrin, liver enzymes, plasma urea and bilirubin were all normal.
A woman with beta-thalassemia gave birth to an infant by cesarean section and breastfed her infant (extent not stated) from birth while receiving deferoxamine (dosage not stated). No adverse effects were reported in her infant.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
