8-O-acetylneoline | 60158-58-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 8-O-acetylneoline
• 英文别名: delphidine；[(1S,2R,3R,4S,5S,6S,8R,9R,13S,16S,17R,18R)-11-ethyl-4,16-dihydroxy-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-8-yl] acetate
• CAS: 60158-58-9
• 化学式: C₂₆H₄₁NO₇
• 分子量: 479.614
• InChiKey: VGFCHANRXLYUOQ-QZWKFOKCSA-N

物化性质

• 沸点：
  570.9±50.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  97.7
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  甲醇 、 8-O-acetylneoline 反应 48.0h， 以22.5 mg的产率得到8-O-methyl-1-epi-neoline
  参考文献：
  名称：

  降二萜生物碱飞燕草的 α-OH-1 基团不寻常的差向异构化

  摘要：

  摘要 Delphisine 在回流甲醇中的溶剂分解得到 8-deacetyl-8-O-methyl-1-epi-delphisine。类似地，delphisine 在沸水中水解得到 14-O-乙酰基-1-epi-neoline，8-O-acetylneoline 在甲醇中的溶剂分解得到 8-O-methyl-1-epi-neoline。产品的结构已通过光谱数据和与真实样品的比较得到证实。为了发生差向异构化，α-OH-1 和 OAc-8 基团都是必需的。讨论了差向异构化的机制。

  DOI：

  10.1016/0031-9422(90)85293-o
• 作为产物：
  描述：

  delphisine 在 氢溴酸 作用下， 反应 96.0h， 以20.3 mg的产率得到8-O-acetylneoline
  参考文献：
  名称：

  Liang, Xihui; Desai, Haridutt K.; Joshi, Balawant S., Heterocycles, 1990, vol. 31, # 10, p. 1889 - 1894

  摘要：

  DOI：

文献信息

• COMPOSITIONS RICH IN OMEGA-3 FATTY ACIDS WITH A LOW CONTENT IN PHYTANIC ACID
  申请人：NATAC PHARMA, S.L.

  公开号：EP2429317B2

  公开（公告）日：2019-02-20
• UTILISATION D'AU MOINS UN ACIDE GRAS OMEGA-3 ET D'AU MOINS UN POLYPHENOL POUR LA SYNTHESE ENDOGENE D'ACIDE EICOSAPENTAENOIQUE ET D'ACIDE DOCOSAHEXAENOIQUE
  申请人：Universite Joseph Fourier (Grenoble 1)

  公开号：EP2453888A1

  公开（公告）日：2012-05-23
• MEDICAL PRODUCT FOR TREATING STENOSIS OF BODY PASSAGES AND FOR PREVENTING THREATENING RESTENOSIS
  申请人：Hoffmann Erika

  公开号：US20100179475A1

  公开（公告）日：2010-07-15

  A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
• Balloon Catheter for Treating Stenosis of Body Passages and for Preventing Threatening Restenosis
  申请人：Hoffmann Erika

  公开号：US20110160698A1

  公开（公告）日：2011-06-30

  The present invention is directed to a method for coating catheter balloons with a defined amount of a pharmacologically active agent, wherein the coating method uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.
• TRANSGENIC PLANTS FOR ENHANCING ANTHOCYANIN BIOSYNTHESIS
  申请人：University-Industry Cooperation Group of Kyung Hee University

  公开号：US20170211079A1

  公开（公告）日：2017-07-27

  The present invention relates to a transgenic plant with enhanced anthocyanin biosynthesis by the introduction of PtrMYB119 gene operably linked to a promoter, a method for preparing the transgenic plant, a method for producing anthocyanin from the transgenic plant, a composition for promoting anthocyanin biosynthesis comprising PtrMYB119 gene operably linked to a promoter, a kit for promoting anthocyanin biosynthesis comprising the composition, and a method for enhancing anthocyanin biosynthesis in a plant comprising introducing the composition into a plant for its expression. The use of the composition for enhancing anthocyanin biosynthesis provided in the present invention enables large-scale production of anthocyanins without any affect on the growth of the plant cell, which is a host, and thus the composition can be widely used for more effective production of anthocyanins.