Synthesis and anti-glioma activity of 25(R)-spirostan-3β,5α,6β,19-tetrol
摘要:
Malignant gliomas are common and aggressive brain rumours in adults. The rapid proliferation and diffuse brain migration are the main obstacles to successful treatment. Here, we show 25(R)-spirostan-3 beta,5 alpha,6 beta,19-tetrol, a polyhydroxy steroid, is capable of suppressing proliferation and Migration Of C6 malignant glioma cells in a concentration-dependent manner. The compound 25(R)-spirostan-3 beta,5 alpha,6 beta,19-tetrol was synthesised by seven steps starting from diosgenin in 8.55% overall yield. The structures of the synthetic compounds were characterised by infrared (IR), (1)H nuclear magnetic resonance (NMR), (13)C NMR spectra and EA. (C) 2009 Elsevier Inc. All rights reserved.