methyl 3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranoside | 1029931-22-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranoside
• CAS: 1029931-22-3
• 化学式: C₃₉H₄₈O₅Si₂
• 分子量: 652.978
• InChiKey: QVBBHKOFMZKRDP-TXCFPHOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.65
• 重原子数：
  46.0
• 可旋转键数：
  10.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.15
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl 3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranoside 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以96%的产率得到3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranose
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043
• 作为产物：
  描述：

  (1S,4R,7S)-1-(hydroxymethyl)-3-methoxy-2,5-dioxabicyclo[2.2.1]heptan-7-ol 、 叔丁基二苯基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以1.23 g的产率得到methyl 3,5-di-O-tert-butyldiphenylsilyl-2-O,4-C-methylene-D-ribofuranoside
  参考文献：
  名称：

  Recognition of T·A interruption by 2′,4′-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation

  摘要：

  2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) monomers bearing novel unnatural nucleobases, 4-(3-benzamidophenyl)-2-pyridone and 2-(N-methylbenzamido)thiazole, were synthesized and successfully incorporated into oligonucleotides. UV melting experiments showed that the corresponding oligonucleotide derivatives formed stable triplexes with dsDNA targets even in the presence of a T center dot A interruption. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.043