(4S,5S,8S,9S,10S,13S,14S,17R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-2-[1-hydroxy-meth-(Z)-ylidene]-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one | 33426-04-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4S,5S,8S,9S,10S,13S,14S,17R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-2-[1-hydroxy-meth-(Z)-ylidene]-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one
• CAS: 33426-04-9
• 化学式: C₃₀H₄₈O₃
• 分子量: 456.709
• InChiKey: LFTRQEFDRDKOGK-CQOQCDKXSA-N

反应信息

• 作为反应物：
  描述：

  (4S,5S,8S,9S,10S,13S,14S,17R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-2-[1-hydroxy-meth-(Z)-ylidene]-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one 生成 (5R,8S,9S,10R,13S,14S,17R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one
  参考文献：
  名称：

  Synthese und Biologische Auswertung von 3?,20(R)-Dihydroxy-Protost-24-en

  摘要：

  AbstractThe possible lanosterol precursor, 3β, 20(R)‐dihydroxy‐protost‐24‐ene (1 a) has been prepared, in thirteen steps, from 3α‐hydroxy‐4α, 8, 14‐trimethyl‐18‐nor‐5α, 8α, 9β, 13ξ, 14β‐androstan‐17‐one (mixture of 2 and 3). In vitro experiments with rat liver homogenates failed to convert 1 a to lanosterol.

  DOI：

  10.1002/hlca.19710540515
• 作为产物：
  描述：

  在 sodium hydride 、 溶剂黄146 作用下， 生成 (4S,5S,8S,9S,10S,13S,14S,17R)-17-((R)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-2-[1-hydroxy-meth-(Z)-ylidene]-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one
  参考文献：
  名称：

  Synthese und Biologische Auswertung von 3?,20(R)-Dihydroxy-Protost-24-en

  摘要：

  AbstractThe possible lanosterol precursor, 3β, 20(R)‐dihydroxy‐protost‐24‐ene (1 a) has been prepared, in thirteen steps, from 3α‐hydroxy‐4α, 8, 14‐trimethyl‐18‐nor‐5α, 8α, 9β, 13ξ, 14β‐androstan‐17‐one (mixture of 2 and 3). In vitro experiments with rat liver homogenates failed to convert 1 a to lanosterol.

  DOI：

  10.1002/hlca.19710540515