3-(2-bromo-5-hydroxyphenyl)prop-2-enamide | 1000562-57-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(2-bromo-5-hydroxyphenyl)prop-2-enamide
• CAS: 1000562-57-1
• 化学式: C₉H₈BrNO₂
• 分子量: 242.072
• InChiKey: WVGLYESFPCGOPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丙烯酸叔丁酯 、 3-(2-bromo-5-hydroxyphenyl)prop-2-enamide 在 四(三苯基膦)钯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以95%的产率得到
  参考文献：
  名称：

  Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor

  摘要：

  Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.010
• 作为产物：
  描述：

  2-Bromo-5-hydroxycinnamic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 ammonium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.5h， 以62%的产率得到3-(2-bromo-5-hydroxyphenyl)prop-2-enamide
  参考文献：
  名称：

  Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor

  摘要：

  Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.010

文献信息

• [EN] COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT D'UNE FIBROSE PULMONAIRE
  申请人：VECTUS BIOSYSTEMS LTD

  公开号：WO2018018091A1

  公开（公告）日：2018-02-01

  The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.

  本发明涉及化合物及其在预防及/或治疗肺纤维化及/或相关病症的应用。
• [EN] COMPOSITIONS FOR THE TREATMENT OF KIDNEY AND/OR LIVER DISEASE<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT D'UNE MALADIE HÉPATIQUE ET/OU RÉNALE
  申请人：VECTUS BIOSYSTEMS LTD

  公开号：WO2016145478A1

  公开（公告）日：2016-09-22

  The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of kidney and/or liver disease.

  本发明涉及新化合物及其在预防性和/或治疗性治疗肾脏和/或肝脏疾病中的用途。
• Compositions for the treatment of kidney and/or liver disease
  申请人：VECTUS BIOSYSTEMS LIMITED

  公开号：US10183908B2

  公开（公告）日：2019-01-22

  The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of kidney and/or liver disease.

  本发明涉及新型化合物及其在预防和/或治疗肾脏和/或肝脏疾病中的用途。
• Compositions for the treatment of pulmonary fibrosis
  申请人：Vectus Biosystems Limited

  公开号：US10919863B2

  公开（公告）日：2021-02-16

  The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.

  本发明涉及化合物及其在肺纤维化和/或相关疾病的预防和/或治疗中的用途。
• COMPOSITIONS FOR THE TREATMENT OF KIDNEY AND/OR LIVER DISEASE
  申请人：Vectus Biosystems Limited

  公开号：EP3271326A1

  公开（公告）日：2018-01-24