6-deoxy-6-(3'-((2"-pyridyl)dithio)-propionamido)-β-cyclodextrin | 1002934-08-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-deoxy-6-(3'-((2"-pyridyl)dithio)-propionamido)-β-cyclodextrin
• CAS: 1002934-08-8
• 化学式: C₅₀H₇₈N₂O₃₅S₂
• 分子量: 1331.29
• InChiKey: UFWPRFXRGNJTBI-QQXOQPBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.88
• 重原子数：
  89.0
• 可旋转键数：
  13.0
• 环数：
  22.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  575.81
• 氢给体数：
  21.0
• 氢受体数：
  38.0

反应信息

• 作为产物：
  描述：

  3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯 、 单-6-O-氨基-Β-环糊精 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以86%的产率得到6-deoxy-6-(3'-((2"-pyridyl)dithio)-propionamido)-β-cyclodextrin
  参考文献：
  名称：

  [EN] CYCLODEXTRIN CONJUGATES
  [FR] CONJUGUÉS DE CYCLODEXTRINE

  摘要：

  描述了一种环糊精-RNA共轭物，其中环糊精分子通过其葡萄糖基的6号、2号或3号位置（可选地通过连接剂）与至少一个RNA分子的RNA 3'末端碱基结合。至少一个RNA分子可以是siRNA分子。

  公开号：

  WO2018109138A1

文献信息

• Protein Nanopores with Covalently Attached Molecular Adapters
  作者：Hai-Chen Wu、Yann Astier、Giovanni Maglia、Ellina Mikhailova、Hagan Bayley

  DOI：10.1021/ja0761840

  日期：2007.12.1

  Molecular adapters are crucial for the stochastic sensing of organic analytes with (x-hemolysin (alpha HL) protein nanopores when direct interactions between analytes and the pore cannot readily be arranged by conventional protein engineering. In our earlier studies, cyclodextrin adapters were lodged noncovalently within the lumen of the (alpha HL pore. In the present work, we have realized the controlled covalent attachment of a beta-cycloclextrin (beta CD) adapter in the two possible molecular orientations inside alpha HL pores prepared by genetic engineering. There are two advantages to such a covalent system. First, the adapter cannot dissociate, which means there are no gaps during stochastic detection, a crucial advance for single-molecule exonuclease DNA sequencing where the continuous presence of a molecular adapter will be essential for reading individual nucleotides. Second, the ability to orient the adapter allows analytes to bind through only one of the two entrances to the PCD cavity. We demonstrate that the covalently attached adapters can be used to alter the ion selectivity of the alpha HL pore, examine binding events at elevated temperatures, and detect analytes with prolonged dwell times.