Methyl 7-(5-methyl-2,4-dioxooxolan-3-yl)-7-oxoheptanoate | 662151-96-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 7-(5-methyl-2,4-dioxooxolan-3-yl)-7-oxoheptanoate
• CAS: 662151-96-4
• 化学式: C₁₃H₁₈O₆
• 分子量: 270.282
• InChiKey: YQHFFPSQGGRJJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 7-(5-methyl-2,4-dioxooxolan-3-yl)-7-oxoheptanoate 在 盐酸 、 silica gel 、 sodium cyanoborohydride 作用下， 以 甲醇 、 溶剂黄146 、 甲苯 为溶剂， 反应 5.0h， 生成 7-(2-甲基-5-氧代-2H-呋喃-4-基)庚酸甲酯
  参考文献：
  名称：

  Heterocyclic Analogs of Prostaglandins: I. Synthesis of 3-Alkyl(Aralkyl)-2,5-dihydrofuran-2-ones as Synthons for 11-Deoxy-10-oxaprostanoids

  摘要：

  3-Acyl(arylmethyleneacyl)tetronic acids were synthesized. Selective hydrogenation of the carbonyl group in the acyl fragment and reduction of the conjugated double bond afforded in high yield the corresponding 3-alkyl(aralkyl) derivatives possessing either natural or modified prostaglandin alpha-chain. Reduction of the conjugated double bond in vinylogous 3-alkyl(aralkyl)tetronic acid amides with sodium cyanotrihydridoborate gave a mixture of stereoisomeric beta-amino lactones which underwent retro-Michael elimination of the amine residue, leading to 3-alkyl(aralkyl)-2,5-dihydrofuran-2-ones. The latter can be regarded as synthons for 11-deoxy-10-oxaprostanoids.

  DOI：

  10.1023/b:rujo.0000003193.75790.de
• 作为产物：
  描述：

  7-甲氧基-7-氧代庚酸 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 丙酮 作用下， 以 四氢呋喃 、 氯仿 、 甲苯 为溶剂， 反应 18.0h， 生成 Methyl 7-(5-methyl-2,4-dioxooxolan-3-yl)-7-oxoheptanoate
  参考文献：
  名称：

  Heterocyclic Analogs of Prostaglandins: I. Synthesis of 3-Alkyl(Aralkyl)-2,5-dihydrofuran-2-ones as Synthons for 11-Deoxy-10-oxaprostanoids

  摘要：

  3-Acyl(arylmethyleneacyl)tetronic acids were synthesized. Selective hydrogenation of the carbonyl group in the acyl fragment and reduction of the conjugated double bond afforded in high yield the corresponding 3-alkyl(aralkyl) derivatives possessing either natural or modified prostaglandin alpha-chain. Reduction of the conjugated double bond in vinylogous 3-alkyl(aralkyl)tetronic acid amides with sodium cyanotrihydridoborate gave a mixture of stereoisomeric beta-amino lactones which underwent retro-Michael elimination of the amine residue, leading to 3-alkyl(aralkyl)-2,5-dihydrofuran-2-ones. The latter can be regarded as synthons for 11-deoxy-10-oxaprostanoids.

  DOI：

  10.1023/b:rujo.0000003193.75790.de