6-hepten-2-ynal | 82523-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-hepten-2-ynal
• 英文别名: hept-6-en-2-ynal
• CAS: 82523-29-3
• 化学式: C₇H₈O
• 分子量: 108.14
• InChiKey: VWRNVBFMGXJYPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  8.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-碘-2-甲基丁-1-烯 、 6-hepten-2-ynal 在 叔丁基锂 作用下， 以 乙醚 、 正戊烷 为溶剂， 以48%的产率得到2-methyl-1,10-undecadiene-6-yn-5-ol
  参考文献：
  名称：

  Palladium-Catalyzed Highly Diastereoselective Cyclic Carbopalladation−Carbonylative Esterification Tandem Reaction of Iododienes and Iodoarylalkenes

  摘要：

  [GRAPHICS]Pd-catalyzed reaction of iododienes and iodoarylalkenes represented by 1, 8, and 10 under 1 atm of CO and a small amount of O-2 in the presence of a base, e.g., NEt3 as well as MeOH and H2O in DMF can undergo a highly diastereoselective cyclic carbopalladation-carbonylative esterification tandem process (Type II C-Pd process) to give in high yields the corresponding ester-containing cyclization products, e.g., 2, 9, and 11, in as high as 98% diastereoselectivity.

  DOI：

  10.1021/ol9900663
• 作为产物：
  描述：

  庚-6-烯-2-炔-1-醇 在 Celite 、 pyridinium chlorochromate 作用下， 反应 3.0h， 以55%的产率得到6-hepten-2-ynal
  参考文献：
  名称：

  Palladium-Catalyzed Highly Diastereoselective Cyclic Carbopalladation−Carbonylative Esterification Tandem Reaction of Iododienes and Iodoarylalkenes

  摘要：

  [GRAPHICS]Pd-catalyzed reaction of iododienes and iodoarylalkenes represented by 1, 8, and 10 under 1 atm of CO and a small amount of O-2 in the presence of a base, e.g., NEt3 as well as MeOH and H2O in DMF can undergo a highly diastereoselective cyclic carbopalladation-carbonylative esterification tandem process (Type II C-Pd process) to give in high yields the corresponding ester-containing cyclization products, e.g., 2, 9, and 11, in as high as 98% diastereoselectivity.

  DOI：

  10.1021/ol9900663

文献信息

• Priebe, Hanno; Hopf, Henning, Angewandte Chemie, 1982, vol. 94, # 4, p. 299
  作者：Priebe, Hanno、Hopf, Henning

  DOI：——

  日期：——