7-(2,3-Dihydro-1,1,3,3-tetramethyl-1h-inden-5-yl)-3-methyl-2,4,6-octatrienoic acid | 69251-08-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-(2,3-Dihydro-1,1,3,3-tetramethyl-1h-inden-5-yl)-3-methyl-2,4,6-octatrienoic acid
• 英文别名: (2E,4E,6E)-3-methyl-7-(1,1,3,3-tetramethyl-2H-inden-5-yl)octa-2,4,6-trienoic acid
• CAS: 69251-08-7
• 化学式: C₂₂H₂₈O₂
• 分子量: 324.5
• InChiKey: XAETVFCFSFGPDL-ZLLKFVMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Prevention of glucocorticoid-induced skin atrophy
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0266992A2

  公开（公告）日：1988-05-11

  The present invention is directed to the topical administra­tion of a retinoid-containing pharmaceutical composition for the prevention of glucocorticoid-induced skin atrophy.

  本发明涉及一种含维甲酸的药物组合物的局部用药，用于预防糖皮质激素引起的皮肤萎缩。
• Method for the treatment or prevention of intrinsically aged skin with retinoids
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0379367A2

  公开（公告）日：1990-07-25

  A method for the treatment or prevention of intrinsically aged skin by the topical administration of retinoids is described.

  本文介绍了一种通过局部使用维甲酸来治疗或预防内在老化皮肤的方法。
• Use of retinoids for preventing and reducing the size of striae distensae lesions
  申请人：Kligman, Albert M.

  公开号：EP0415458A2

  公开（公告）日：1991-03-06

  Striae distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of a retinoid, preferably retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0.025 to 0.1 weight percent retinoic acid. When applied during the striae rubrae stage, the retinoid may be effective to prevent the formation of striae albae lesions, and when applied in either stage, the retinoid may be effective to reduce the width and depth of the lesions, with improved texture and softness.

  可通过在受皮损影响的皮肤上局部施用有效量的维甲酸（最好是维甲酸）来防止和/或缩小红斑皮损，维甲酸的浓度最好为 0.025 至 0.1 重量百分比。在红斑期施用时，维甲酸可有效防止白斑的形成；在任何一个阶段施用时，维甲酸可有效减少皮损的宽度和深度，并改善质地和柔软度。
• Use of retinoids for reversing glucocorticoid-induced skin atrophy
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0415766A2

  公开（公告）日：1991-03-06

  The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.

  本发明涉及一种含维甲酸的药物组合物的局部用药，用于逆转糖皮质激素诱导的皮肤萎缩的影响。
• Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
  申请人：Advanced Polymer Systems, Inc.

  公开号：EP0781551A1

  公开（公告）日：1997-07-02

  Retinoids for topical skin application are formulated as impregnants in porous microspheres. Thus formulated, the retinoids display a surprisingly high level of stability and low degree of skin irritation.

  用于局部皮肤应用的维甲酸被配制成多孔微球中的浸渍剂。这样配制的维甲酸具有惊人的高稳定性和低皮肤刺激性。