5,7-Dichlor-8-methoxychinolin | 17012-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,7-Dichlor-8-methoxychinolin
• 英文别名: 5,7-Dichloro-8-methoxyquinoline；5,7-dichloro-8-methoxyquinoline
• CAS: 17012-48-5
• 化学式: C₁₀H₇Cl₂NO
• 分子量: 228.078
• InChiKey: ORWSSBQCXVEDFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-Dichlor-8-methoxychinolin 在 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 15.5h， 生成 8-(tert-butoxy)-5,7-dichloro-2-(trifluoromethyl)quinoline
  参考文献：
  名称：

  Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides

  摘要：

  已开发出一种新颖高效的直接全氟烷基化嗪N-氧化物的方法，并提供了有趣的机理细节。

  DOI：

  10.1039/c4ob01088d

文献信息

• MUTANT ANTIBODIES AND CONJUGATION THEREOF
  申请人：Pfizer Healthcare Ireland

  公开号：US20210147576A1

  公开（公告）日：2021-05-20

  The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β-strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X 1 -X 2 -X 3 -X 4 -K 5 H 6 (SEQ ID NO:98), and X 1 , X 3 and X 4 are each independently any amino acid residue, characterized in that X 2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof
• [EN] MULTIFUNCTIONAL ANTIBODY CONJUGATES<br/>[FR] CONJUGUÉS D'ANTICORPS MULTIFONCTIONNELS
  申请人：COVX TECHNOLOGIES IRELAND LTD

  公开号：WO2012007896A1

  公开（公告）日：2012-01-19

  The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CLκ) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
• [EN] MUTANT ANTIBODIES AND CONJUGATION THEREOF<br/>[FR] ANTICORPS MUTANTS ET LEUR CONJUGAISON
  申请人：COVX TECHNOLOGIES IRELAND LTD

  公开号：WO2013105013A1

  公开（公告）日：2013-07-18

  The present invention relates to a polypeptide comprising 7 β-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first α-helix sequentially located on the EF chain between β-strands E and F, wherein the β-strands are arranged so as to form a first β-sheet comprising β- strands A, B, D, and E, and a second β-sheet comprising β-strands C, F and G, said first and second β-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between β-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof.
• Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides
  作者：David E. Stephens、Gabriel Chavez、Martin Valdes、Monica Dovalina、Hadi D. Arman、Oleg V. Larionov

  DOI：10.1039/c4ob01088d

  日期：——

  Novel and efficient method of direct perfluoroalkylation of azine N-oxides has been developed and interesting mechanistic details have been provided.

  已开发出一种新颖高效的直接全氟烷基化嗪N-氧化物的方法，并提供了有趣的机理细节。