3-碘-8-喹啉醇 | 497084-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-碘-8-喹啉醇
• 英文名称: 3-iodo-8-hydroxyquinoline
• 英文别名: 3-iodo-8-quinolinol；8-Quinolinol, 3-iodo-；3-iodoquinolin-8-ol
• CAS: 497084-48-7
• 化学式: C₉H₆INO
• 分子量: 271.057
• InChiKey: IFMHKXXFNZUDSZ-UHFFFAOYSA-N

物化性质

• 沸点：
  393.5±22.0 °C(Predicted)
• 密度：
  1.974±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-I碘-8-硝基喹啉 在 盐酸 、 硫酸 、 铁粉 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 3-碘-8-喹啉醇
  参考文献：
  名称：

  Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols

  摘要：

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.

  DOI：

  10.1007/s00706-002-0495-6

文献信息

• [EN] QUINOLINE DERIVATIVES FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] DÉRIVÉS DE QUINOLÉINE POUR LE DIAGNOSTIC ET LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：UNIV NORTHEASTERN

  公开号：WO2016183578A1

  公开（公告）日：2016-11-17

  A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents, which can be used for early detection of aggregates in the brain or other tissues prior to onset of symptoms, allowing early therapeutic intervention. The compounds are also useful for the prevention and treatment of such diseases.

  一类新的喹啉化合物对于检测和治疗阿尔茨海默病和其他神经退行性疾病，如淀粉样蛋白病和tau蛋白病具有用处。这些化合物可以以放射标记形式合成，用作成像剂，可用于在症状发作之前早期检测大脑或其他组织中的聚集物，从而实现早期治疗干预。这些化合物还可用于预防和治疗这些疾病。
• Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease
  申请人：Northeastern University

  公开号：US20180141911A1

  公开（公告）日：2018-05-24

  A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents, which can be used for early detection of aggregates in the brain or other tissues prior to onset of symptoms, allowing early therapeutic intervention. The compounds are also useful for the prevention and treatment of such diseases.
• Preparation and Antifungal Activity of 3-Iodo- and 6-Iodo-8-quinolinols
  作者：Herman Gershon、Donald D. Clarke、John J. McMahon、Muriel Gershon

  DOI：10.1007/s00706-002-0495-6

  日期：2002.9.1

  3-Iodo- and 6-Iodo-8-quinolinols were prepared and tested against six fungi: Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichopkyton mentagrophytes in Sabouraud dextrose broth. A comparison with the previously known 5-iodo- and 7-iodo-8-quinolinols showed that the 6-iodo isomer was the most active.