(3-trifluoroacetamidopropyl)-2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-{2,4-di-O-acetyl-6-O-benzyl-3-O-[2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-(2,4-di-O-acetyl-6-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranosyl}-β-D-glucopyranoside | 1155352-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-trifluoroacetamidopropyl)-2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-{2,4-di-O-acetyl-6-O-benzyl-3-O-[2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-(2,4-di-O-acetyl-6-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranosyl}-β-D-glucopyranoside
• CAS: 1155352-44-5
• 化学式: C₇₃H₉₀F₃N₃O₂₈
• 分子量: 1514.52
• InChiKey: SYGVEOCDCLSLOT-AMPBPMHYSA-N

反应信息

• 作为反应物：
  描述：

  、 (3-trifluoroacetamidopropyl)-2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-{2,4-di-O-acetyl-6-O-benzyl-3-O-[2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-(2,4-di-O-acetyl-6-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranosyl}-β-D-glucopyranoside 在 silver trifluoromethanesulfonate 、 1,1,3,3-四甲基脲 作用下， 以 二氯甲烷 为溶剂， 以47%的产率得到
  参考文献：
  名称：

  The synthesis of linear trilactosamine

  摘要：

  TrilactosamineGal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta-sp, where sp = O(CH(2))(3)NH(2) is a spacer, was synthesized. The tetrasaccharide fragment Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta-sp was obtained by successive glycosylation using elongation by one monosaccharide residue at a time; and the tetrasaccharide was then transformed into a hexasaccharide with a disaccharide glycosyl donor. A 2,2,2-trichloroethoxycarbonyl group was used for the protection of the glucosamine amino group.

  DOI：

  10.1134/s1068162008050129
• 作为产物：
  描述：

  、 乙酸酐 、 原乙酸三乙酯 在 对甲苯磺酸 、 吡啶 、 水 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以48%的产率得到(3-trifluoroacetamidopropyl)-2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-{2,4-di-O-acetyl-6-O-benzyl-3-O-[2-acetamido-3-O-acetyl-6-O-benzyl-2-deoxy-4-O-(2,4-di-O-acetyl-6-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranosyl}-β-D-glucopyranoside
  参考文献：
  名称：

  The synthesis of linear trilactosamine

  摘要：

  TrilactosamineGal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta-sp, where sp = O(CH(2))(3)NH(2) is a spacer, was synthesized. The tetrasaccharide fragment Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4GlcNAc beta-sp was obtained by successive glycosylation using elongation by one monosaccharide residue at a time; and the tetrasaccharide was then transformed into a hexasaccharide with a disaccharide glycosyl donor. A 2,2,2-trichloroethoxycarbonyl group was used for the protection of the glucosamine amino group.

  DOI：

  10.1134/s1068162008050129