tert-butyldimethylsilyl (methyl 4-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-β-D-glucopyranoside | 1092935-58-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyldimethylsilyl (methyl 4-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-β-D-glucopyranoside
• CAS: 1092935-58-4
• 化学式: C₅₁H₆₂N₆O₁₄Si
• 分子量: 1011.17
• InChiKey: SVTQJTCWBRZFQI-AIVRFTTDSA-N

反应信息

• 作为反应物：
  描述：

  tert-butyldimethylsilyl (methyl 4-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-β-D-glucopyranoside 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 以86%的产率得到(methyl 4-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-α/β-D-glucopyranose
  参考文献：
  名称：

  Synthesis of a tetrasaccharide substrate of heparanase

  摘要：

  A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely beta-D-GIcA(2S)-(1 -> 4)-alpha-D-GIcN(NS,6S)-(1 -> 4)-beta-D-GIcA-(1 -> 4)-alpha-D-GIcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.06.011
• 作为产物：
  描述：

  tert-butyldimethylsilyl (methyl 2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-β-D-glucopyranoside 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以95%的产率得到tert-butyldimethylsilyl (methyl 4-O-acetyl-2-O-(2-(azidomethyl)benzoyl)-3-O-benzyl-β-D-glucopyranosyluronate)-(1->4)-2-azido-3-O-benzyl-2-deoxy-6-O-(4-methoxybenzyl)-β-D-glucopyranoside
  参考文献：
  名称：

  Synthesis of a tetrasaccharide substrate of heparanase

  摘要：

  A tetrasaccharide, corresponding to the heparan sulfate heparanase substrate, namely beta-D-GIcA(2S)-(1 -> 4)-alpha-D-GIcN(NS,6S)-(1 -> 4)-beta-D-GIcA-(1 -> 4)-alpha-D-GIcN(NS,6S)-OMe, was synthesized in a convergent manner via coupling of a pair of the disaccharide building blocks as a key step. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.06.011