| 1038899-78-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1038899-78-3
• 化学式: C₄₆H₅₁N₃O₁₃
• 分子量: 853.923
• InChiKey: UIHZPLHBUDSZQZ-DLUHDUGVSA-N

反应信息

• 作为反应物：
  描述：

  在 溶剂黄146 、 乙二胺 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以64%的产率得到
  参考文献：
  名称：

  Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties

  摘要：

  Stimulation of iNKT cells is highly dependent on the structures of the glycolipids presented by CD1d. Furthermore, antigen processing and CD1d loading in lysosomes play central roles in controlling the stimulatory properties of glycolipid antigens. Previously, we determined that substitution at C6 '' on alpha-galactosylceramides did not significantly impact stimulatory properties; however, it was not known if substitution at this position influenced lysosomal processing of oligoglycosylceramides. We have prepared a series of mono- and di-galactosylceramides to observe the impact of C6 '' substitution on glycosidase truncation of these glycolipids. We found that substitution did not significantly impact glycosidase activity or loading into CD1d. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.067
• 作为产物：
  描述：

  、 2,3,4,6-四-O-苄基-D-吡喃半乳糖三氯乙亚氨酸酯 在 三氟甲磺酸三甲基硅酯 、 4 A molecular sieve 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以37%的产率得到
  参考文献：
  名称：

  Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties

  摘要：

  Stimulation of iNKT cells is highly dependent on the structures of the glycolipids presented by CD1d. Furthermore, antigen processing and CD1d loading in lysosomes play central roles in controlling the stimulatory properties of glycolipid antigens. Previously, we determined that substitution at C6 '' on alpha-galactosylceramides did not significantly impact stimulatory properties; however, it was not known if substitution at this position influenced lysosomal processing of oligoglycosylceramides. We have prepared a series of mono- and di-galactosylceramides to observe the impact of C6 '' substitution on glycosidase truncation of these glycolipids. We found that substitution did not significantly impact glycosidase activity or loading into CD1d. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.067