N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide | 1450654-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
• 英文别名: N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[1-(oxan-4-yl)ethyl]indole-3-carboxamide
• CAS: 1450654-49-5
• 化学式: C₂₅H₃₁N₃O₄
• 分子量: 437.539
• InChiKey: PFPSFENQCNMITC-UHFFFAOYSA-N

物化性质

• 沸点：
  712.2±60.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 在 Chiralpak IA column 作用下， 以 甲醇 、 正己烷 、 二氯甲烷 、 二乙胺 为溶剂， 生成 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 、 (S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
  [FR] COMPOSÉS HÉTÉROARYLES BICYCLIQUES FUSIONNÉS EN 6,5 OU BENZÈNES SUBSTITUÉS

  摘要：

  公开号：

  WO2015200650A9
• 作为产物：
  描述：

  2-(2-溴苯基)乙酸甲酯 在 乙醇 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 sodium methylate 、 溶剂黄146 、 三乙胺 、 sodium hydroxide 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 二甲基亚砜 、 甲苯 为溶剂， 反应 45.75h， 生成 N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
  [FR] COMPOSÉS HÉTÉROARYLES BICYCLIQUES FUSIONNÉS EN 6,5 OU BENZÈNES SUBSTITUÉS

  摘要：

  公开号：

  WO2015200650A9

文献信息

• MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
  申请人：CONSTELLATION PHARMACEUTICALS, INC.

  公开号：US20150376190A1

  公开（公告）日：2015-12-31

  Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.

  本文提供了具有结构式（II）的制剂，用于调节组蛋白甲基修饰酶，例如作为抗癌制剂的组合物和用途。
• SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
  申请人：Epizyme, Inc.

  公开号：US20170217941A1

  公开（公告）日：2017-08-03

  The present invention relates to substituted benzene compounds and bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
• INHIBITION OF PRC2 SUBUNITS TO TREAT EYE DISORDERS
  申请人：FONDATION ASILE DES AVEUGLES

  公开号：US20210213013A1

  公开（公告）日：2021-07-15

  The present disclosure provides inhibitors of one or more subunits of polycomb repressive complex 2 (PRC2) for use in the prevention or the treatment of an eye disorder in a subject in need thereof and methods for treating an eye disorder, e.g. non-cancer disorders, in a subject using a therapeutically effective amount of one or more inhibitors of a subunit of polycomb repressive complex 2 (PRC2). In certain embodiments of the methods of the disclosure, the eye disorders are characterized by degeneration or cell death of retinal neurons. In certain embodiments of the methods of the disclosure, the subunit of PRC2 is EZH1 or EZH2, and the inhibitor is an inhibitor of H3K27 trimethylation.
• US9980952B2
  申请人：——

  公开号：US9980952B2

  公开（公告）日：2018-05-29