8-Hydroxy-quinoline-2-carboxylic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide | 65625-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Hydroxy-quinoline-2-carboxylic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
• 英文别名: 8-hydroxy-N’-(2-hydroxybenzylidene)quinoline-2-carbohydrazide
• CAS: 65625-17-4
• 化学式: C₁₇H₁₃N₃O₃
• 分子量: 307.309
• InChiKey: DLSSKFZRDCLUEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.81
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  氢化铝 、 8-Hydroxy-quinoline-2-carboxylic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide 以 水 、 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  Fluorescent schiff base probes for sequential detection of Al3+ and F− and cell imaging applications

  摘要：

  Two novel Schiff-base fluorescent probers SQ and NQ based on 8-hydroxyquinoline moiety were designed and synthesized. The both probes were capable of binding with Al3+ by naked eye detection to produce a significant fluorescence enhancement response with a detection limit of 1.48 x 10(-8) and 4.23 x 10(-8) M, respectively. At the same time, the formed complexes SQ-Al3+ and NQ-Al3+ could sequentially detect F-, and the detection limits of F- were determined to be 1.64 x 10(-7) and 3.58 x 10(-8) M, respectively. The "off-on-off" fluorescence response process demonstrated that the binding were reversible. The probes were further successfully utilized to detect Al3+ and E in vitro PC12 cells. (C) 2019 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2019.117678
• 作为产物：
  描述：

  8-羟基喹啉-2-甲醛 在 甲酸 、 氯化亚砜 、 双氧水 、 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 28.0h， 生成 8-Hydroxy-quinoline-2-carboxylic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Fluorescent schiff base probes for sequential detection of Al3+ and F− and cell imaging applications

  摘要：

  Two novel Schiff-base fluorescent probers SQ and NQ based on 8-hydroxyquinoline moiety were designed and synthesized. The both probes were capable of binding with Al3+ by naked eye detection to produce a significant fluorescence enhancement response with a detection limit of 1.48 x 10(-8) and 4.23 x 10(-8) M, respectively. At the same time, the formed complexes SQ-Al3+ and NQ-Al3+ could sequentially detect F-, and the detection limits of F- were determined to be 1.64 x 10(-7) and 3.58 x 10(-8) M, respectively. The "off-on-off" fluorescence response process demonstrated that the binding were reversible. The probes were further successfully utilized to detect Al3+ and E in vitro PC12 cells. (C) 2019 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2019.117678