[Z]-2'-chloroenglerin A | 1357080-60-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [Z]-2'-chloroenglerin A
• 英文别名: NSC#746567；[(1S,2R,5R,6R,7S,8R,10R)-10-(2-hydroxyacetyl)oxy-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] (Z)-2-chloro-3-phenylprop-2-enoate
• CAS: 1357080-60-4
• 化学式: C₂₆H₃₃ClO₆
• 分子量: 476.997
• InChiKey: CEKHKHUEAISXDF-WIHAEEFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2',3'-dichlorodihydroenglerin A 在 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 12.0h， 以2 mg的产率得到[Z]-2'-chloroenglerin A
  参考文献：
  名称：

  Chlorinated Englerins with Selective Inhibition of Renal Cancer Cell Growth

  摘要：

  The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).

  DOI：

  10.1021/np200905u

文献信息

• Chlorinated Englerins with Selective Inhibition of Renal Cancer Cell Growth
  作者：Rhone K. Akee、Tanya Ransom、Ranjala Ratnayake、James B. McMahon、John A. Beutler

  DOI：10.1021/np200905u

  日期：2012.3.23

  The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal cancer cells. The compounds were shown to be extraction artifacts produced by exposure to chloroform decomposition products during their isolation. The most active compound, 3, was synthesized from englerin A (1).