| 1178528-77-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1178528-77-2
• 化学式: C₁₉H₂₅N₃O₇S
• 分子量: 439.489
• InChiKey: PSHKDGNFYFMRSJ-YRIWUQCMSA-N

反应信息

• 作为反应物：
  描述：

  、 溴甲苯 在 四丁基碘化铵 、 sodium hydride 、 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  Synthetic study on α(2→8)-linked oligosialic acid employing 1,5-lactamization as a key step

  摘要：

  An attempt to synthesize alpha(2 -> 8)-linked oligosialic acid utilizing a 1,5-lactamized sialyl acceptor is described. 1,5-Lactamization was experimentally proven to proceed only for alpha-sialoside, which was integrated into the synthetic cycle of oligosialic acid as a chemical sorting step to collect the desired alpha-sialoside and as a transformation step to produce a reactive sialyl acceptor for the next sialylation. Lactarnized oligosialyl acceptors served as favorable coupling partners for sialylation, providing high stereoselectivities and high yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.057
• 作为产物：
  描述：

  methyl (2R,4S,5R,6R)-4-acetyloxy-5-azido-2-phenylsulfanyl-6-[(1S,2R)-1,2,3-triacetyloxypropyl]oxane-2-carboxylate 、 2,2-二甲氧基丙烷 在 sodium methylate 、 D(+)-10-樟脑磺酸 作用下， 以 甲醇 、 乙腈 为溶剂， 以91%的产率得到
  参考文献：
  名称：

  Synthetic study on α(2→8)-linked oligosialic acid employing 1,5-lactamization as a key step

  摘要：

  An attempt to synthesize alpha(2 -> 8)-linked oligosialic acid utilizing a 1,5-lactamized sialyl acceptor is described. 1,5-Lactamization was experimentally proven to proceed only for alpha-sialoside, which was integrated into the synthetic cycle of oligosialic acid as a chemical sorting step to collect the desired alpha-sialoside and as a transformation step to produce a reactive sialyl acceptor for the next sialylation. Lactarnized oligosialyl acceptors served as favorable coupling partners for sialylation, providing high stereoselectivities and high yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.057