(E)-3-(5-tert-butyl-2,3-dihydrobenzofuran-7-yl)acrylic acid | 1165739-50-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(5-tert-butyl-2,3-dihydrobenzofuran-7-yl)acrylic acid
• CAS: 1165739-50-3
• 化学式: C₁₅H₁₈O₃
• 分子量: 246.306
• InChiKey: MVQAYXRZPFACJO-SNAWJCMRSA-N

反应信息

• 作为反应物：
  描述：

  (E)-3-(5-tert-butyl-2,3-dihydrobenzofuran-7-yl)acrylic acid 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

  摘要：

  We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.010
• 作为产物：
  描述：

  丙二酸 、 5-tert-butyl-2,3-dihydrobenzofuran-7-carbaldehyde 在 哌啶 、 吡啶 作用下， 反应 2.0h， 以90%的产率得到(E)-3-(5-tert-butyl-2,3-dihydrobenzofuran-7-yl)acrylic acid
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

  摘要：

  We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent Ca-45(2+) uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.010