Dimethyl (2E,2'E)-2,2'-[pyrimidine-4,6-diylbis(oxy-2,1-phenylene)]bis(3-methoxyprop-2-enoate) | 131860-85-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dimethyl (2E,2'E)-2,2'-[pyrimidine-4,6-diylbis(oxy-2,1-phenylene)]bis(3-methoxyprop-2-enoate)
• 英文别名: methyl (E)-2-[2-[6-[2-[(E)-1,3-dimethoxy-3-oxoprop-1-en-2-yl]phenoxy]pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate
• CAS: 131860-85-0
• 化学式: C₂₆H₂₄N₂O₈
• 分子量: 492.5
• InChiKey: BRBWXPDAJKZQEP-PXXPDPNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Methods for Preparing Azoxystrobin and Intermediate Thereof
  申请人：NUTRICHEM COMPANY LIMITED

  公开号：US20160200687A1

  公开（公告）日：2016-07-14

  The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.

  本发明揭示了一种制备由式（1）和（2）表示的阿托霉唑中间体的方法，包括：控制由式（3）表示的化合物与甲氧基钠和4,6-二氯嘧啶接触，以在存在催化剂的情况下获得由式（1）和（2）表示的中间体的混合物，其中催化剂为吡啶环化合物或其盐。本发明还揭示了一种制备阿托霉唑的方法，包括：控制本发明提供的由式（2）表示的中间体，在吡啶环化合物或其盐的催化作用下与2-氰基苯酚反应，以获得由式（4）表示的阿托霉唑化合物。本发明提供的方法具有高转化率、高产品纯度、操作简便方便和环保友好等优点。
• METHODS FOR PREPARING AZOXYSTROBIN AND INTERMEDIATE THEREOF
  申请人：Nutrichem Company Limited

  公开号：EP3042896A1

  公开（公告）日：2016-07-13

  The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.

  本发明公开了一种制备式(1)和(2)代表的唑菌酯中间体的方法，包括：控制式(3)代表的化合物与甲醇钠和4,6-二氯嘧啶接触，得到式(1)和(2)代表的中间体混合物，在存在催化剂的情况下，催化剂为氮杂环化合物或其盐。本发明进一步公开了一种制备唑啉草酯的方法，包括：控制本发明提供的式(2)代表的中间体在氮杂环化合物或其盐的催化作用下与2-氰基苯酚或其盐反应，得到式(4)代表的唑啉草酯化合物。本发明提供的方法具有转化率高、产品纯度高、操作简单方便、环保等优点。
• [EN] METHODS FOR PREPARING AZOXYSTROBIN AND INTERMEDIATE THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION D'AZOXYSTROBINE ET DE SON INTERMÉDIAIRE
  申请人：NUTRICHEM COMPANY LTD

  公开号：WO2015032192A1

  公开（公告）日：2015-03-12

  本发明公开了一种制备式（1）和式（2）所示嘧菌酯中间体的方法，该方法包括：在催化剂存在下，将式（3）所示化合物与甲醇钠及4,6-二氯嘧啶接触，得到式（1）和式（2）所示中间体的混合物，所述催化剂为氮杂二环化合物或其盐。本发明还公开了一种制备嘧菌酯的方法，该方法包括将本发明提供的式（2）所示中间体与2-氰基苯酚或其盐在氮杂二环化合物或其盐的催化下反应，得到式（4）所示嘧菌酯化合物。本发明提供的方法具有转化率高、产品纯度高、操作简便及对环境友好的突出优点。
• METHOD FOR PREPARING AZOXYSTROBIN AND ITS INTERMEDIATES
  申请人：Nutrichem Company Limited

  公开号：US20180141918A1

  公开（公告）日：2018-05-24

  The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.
• US9920015B2
  申请人：——

  公开号：US9920015B2

  公开（公告）日：2018-03-20