6-Chlor-chinolin-carbaldehyd-(3) | 13669-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Chlor-chinolin-carbaldehyd-(3)
• 英文别名: 6-chloro-quinoline-3-carbaldehyde；6-Chloroquinoline-3-carbaldehyde
• CAS: 13669-68-6
• 化学式: C₁₀H₆ClNO
• mdl: MFCD18448895
• 分子量: 191.617
• InChiKey: KLRONTAVJKLJQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氮 、 6-Chlor-chinolin-carbaldehyd-(3) 、 potassium carbonate 、 碘乙烷 在 氮 、 水 、 Brine 、 magnesium sulfate 、 乙酸乙酯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 以gave 6-chloro-3-ethoxyquinoline as a pale brown solid的产率得到6-chloro-3-ethoxyquinoline
  参考文献：
  名称：

  Tyrosine Kinase Inhibitors

  摘要：

  本发明涉及对于治疗细胞增殖性疾病、治疗与MET活性相关的疾病以及抑制受体酪氨酸激酶MET的吡啶并噻唑酮衍生物。本发明还涉及包括这些化合物的组合物以及使用它们治疗哺乳动物癌症的方法。

  公开号：

  US20130158041A1

文献信息

• Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
  申请人：Apodaca Richard

  公开号：US20060173184A1

  公开（公告）日：2006-08-03

  Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

  某些哌嗪基和哌啶基脲类化合物可作为FAAH抑制剂。这些化合物可用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、紊乱和病况的方法。因此，这些化合物可用于治疗焦虑、疼痛、炎症、睡眠障碍、进食障碍或运动障碍（如多发性硬化症）等疾病。
• PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE
  申请人：Apodaca Richard

  公开号：US20100004261A1

  公开（公告）日：2010-01-07

  Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

  某些哌嗪基和哌啶基脲类化合物可用作FAAH抑制剂。这些化合物可以用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态，障碍和病况的方法。因此，这些化合物可以被用于治疗例如焦虑，疼痛，炎症，睡眠障碍，进食障碍或运动障碍（如多发性硬化症）等疾病。
• NOVEL MICROBIOCIDES
  申请人：Stierli Daniel

  公开号：US20100022570A1

  公开（公告）日：2010-01-28

  Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides. Formula (I), wherein X is oxygen or sulfur; A is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, or a phenyl ring; the heterocyclic ring or the phenyl being substituted by the groups R 6 , R 7 and R 8 ; R 6 , R 7 and R 8 are each, independently, hydrogen, halogen, cyano, nitro, C 1-4 alky, C 1-4 halogenalkyl, C 1-4 halogenalkoxy, C 1-4 alkoxy(C 1-4 )alkyl or C 1-4 halo-genalkoxy(C 1-4 )alkyl, provided that at least one of R 6 , R 7 and R 8 is not hydrogen; B is a phenyl, naphthyl or quinolinyl group, which is substituted by one or more substituents R 9 .

  公式（I）的化合物，其中取代基如权利要求1所定义的，适用于作为微生物杀菌剂。公式（I）中，X为氧或硫；A为含有1至3个杂原子的5-或6元杂环，每个杂原子独立地选自氧、氮和硫，或为苯环；杂环或苯环被基团R6、R7和R8取代；R6、R7和R8各自独立地为氢、卤素、氰基、硝基、C1-4烷基、C1-4卤代烷基、C1-4卤代烷氧基、C1-4烷氧（C1-4）烷基或C1-4卤代烷氧基（C1-4）烷基，但至少有一个R6、R7和R8不是氢；B为苯基、萘基或喹啉基，被一个或多个取代基R9取代。
• 4-(BENZYL)-PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP2937341A1

  公开（公告）日：2015-10-28

  Compounds of formula (I): wherein, Z is -N- or >CH; R1 is -H or -C1-4alkyl; Ar1 is 2-thiazoly, 2-pyridy, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-primidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two Ra moieties; where each Ra moiety is independently selected from the group consisting of -C1-4alkyl, -C2-4alkenyl, -OH, -OC1-4alkyl, halo -CF3, -OCF3, -SCF3, -SH, -S(O)0-2C1-4alkyl, -OSO2C1-4alkyl, -CO2C1-4alkyl, -CO2H, -COC1-4alkyl, -N(Rb)Rc, -SO2NRbRc, -NRbSO2R, -C(=O)NRbRc, -NO2, and -CN, wherein Rb and Rc are each independently -H or -C1-4alkyl; and Ar2 is defined in the claims are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

  式(I)化合物：其中，Z 是 -N- 或 >CH；R1 是 -H 或 -C1-4烷基；Ar1 是 2-噻唑基、2-吡啶基、3-吡啶基、4-吡啶基、2-嘧啶基、4-嘧啶基、5-嘧啶基或苯基，各自未被取代或在碳环成员处被一个或两个 Ra 基取代；其中每个 Ra 分子独立地选自由-C1-4-烷基、-C2-4-烯基、-OH、-OC1-4-烷基、卤代 -CF3、-O 、-S 、-SH、-S(O)0-2C1-4-烷基组成的组、-OSO2C1-4烷基、-CO2C1-4烷基、-CO2H、-COC1-4烷基、-N(Rb)Rc、-SO2NRbRc、-NRbSO2R、-C(＝O)NRbRc、-NO2 和-CN，其中 Rb 和 Rc 各自独立地为-H 或-C1-4烷基；和 Ar2 在权利要求中定义的化合物可用作 FAAH 抑制剂。此类化合物可用于治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、失调和病症的药物组合物和方法中。因此，这些化合物可用于治疗焦虑、疼痛、炎症、睡眠障碍、饮食失调或运动障碍（如多发性硬化症）等。
• PIPERIDINE- AND PIPERAZINE-1-CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1836179B1

  公开（公告）日：2015-05-06