4-甲基伞形酮钠盐 | 5980-33-6

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基伞形酮钠盐
• 中文别名: 4-甲基繖形酮钠；7-羟基-4-甲基香豆素钠盐
• CAS: 5980-33-6
• 化学式: C10H8NaO3
• 分子量: 199.16
• InChiKey: KENPYGBXCKRFQR-UHFFFAOYSA-N

物化性质

• 熔点：
  90-92 °C(lit.)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.43
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  T+
• 危险类别码：
  R26/27/28

文献信息

• Enzymatic Assays Using Umbelliferone Substrates with Cyclodextrins in Droplets of Oil
  申请人：Winger Theodore

  公开号：US20110118132A1

  公开（公告）日：2011-05-19

  The invention is directed to droplet actuator devices and assay methods. The method may include, among other things, a method of conducting enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil, the method including incubating a droplet in oil, the droplet preferably comprising an umbelliferone substrate, a sample, and a cyclodextrin compound. The methods may further include a method of substantially eliminating cross-contamination between droplets in enzymatic containing substrate-based bioassays. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the inclusion complex may be formed using cyclodextrins. In yet another embodiment, the invention may provide a method of enhancing hydrolysis of enzymatic substrates. The methods may further include a method of forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the substrate may be a 4-MU- or HMU containing substrate. The inclusion complex may be formed using cyclodextrin.

  本发明涉及液滴操纵器件和测定方法。该方法可能包括使用环糊精在油滴中使用香豆素底物进行酶促反应的方法，该方法包括在油中孵育油滴，油滴优选包括香豆素底物，样品和环糊精化合物。该方法还可以包括在基于底物的生物测定中实现减少液滴间交叉污染的方法。该方法可能包括固定酶促底物，包括与底物形成包含复合物以稳定底物在水环境中，其中可以使用环糊精形成包含复合物。在另一种实施方式中，本发明可能提供一种增强酶促底物水解的方法。该方法还可以包括与底物形成包含复合物以稳定底物在水环境中，其中底物可以是含4-MU或HMU的底物。包含复合物可以使用环糊精形成。
• Method of hydrolyzing an enzymatic substrate
  申请人：Winger Theodore

  公开号：US20120136147A1

  公开（公告）日：2012-05-31

  The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate within an aqueous environment in contact with an oil.

  这项发明涉及液滴操作器件和检测方法。该方法可能包括将酶底物固定，包括在与油接触的水环境中形成与底物的包含物复合物。
• Method of Conducting an Assay
  申请人：Advanced Liquid Logic, Inc.

  公开号：US20140141460A1

  公开（公告）日：2014-05-22

  The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.

  这项发明涉及液滴驱动器装置和测定方法。该发明包括进行测定的测定方法，其中将样品与香豆素衍生物结合，其中样品可能包含能够切割香豆素衍生物的酶，并且香豆素衍生物包括一个或多个修饰基团修饰的香豆素核心。
• NOVEL CELL WALL DECONSTRUCTION ENZYMES OF SCYTALIDIUM THERMOPHILUM, MYRIOCOCCUM THERMOPHILUM, AND AUREOBASIDIUM PULLULANS, AND USES THEREOF
  申请人：CONCORDIA UNIVERSITY

  公开号：US20150175980A1

  公开（公告）日：2015-06-25

  The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, Scytalidium thermophilum strain CBS 625.91, Myriococcum thermophilum strain CBS 389.93, and Aureobasidium pullulans strain ATCC 62921. Uses thereof in various industrial processes such as in biofuels, food preparation, animal feed, pulp and paper, textiles, detergents, waste treatment and others are also disclosed.

  本发明涉及与生物质加工和/或分解（例如，细胞壁分解）相关的活性的新型多肽和酶（例如，热稳定蛋白和酶），以及与之相关的多核苷酸、载体、细胞、组合物和工具，或其功能变体。更具体地说，本发明涉及可从真菌Scytalidium thermophilumstrain CBS 625.91、Myriococcum thermophilumstrain CBS 389.93和Aureobasidium pullulansstrain ATCC 62921中分离的分泌酶。还公开了这些酶在各种工业过程中的用途，例如生物燃料、食品制备、动物饲料、纸浆和纸张、纺织品、洗涤剂、废物处理等。
• Enzyme Assays on a Droplet Actuator
  申请人：ADVANCED LIQUID LOGIC, INC.

  公开号：US20150184219A1

  公开（公告）日：2015-07-02

  The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.

  本发明涉及液滴驱动器装置和检测方法。本发明包括检测方法，用于进行检测，包括将样品与香豆素衍生物结合，其中样品可能包含能够裂解香豆素衍生物的酶，并且香豆素衍生物包括经过一个或多个修饰基修饰的香豆素核心。