| 943967-08-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 943967-08-6
• 化学式: C₆₇H₇₇N₅O₂₃
• 分子量: 1320.37
• InChiKey: JNYJRRMNXBXVRD-RZPQMECWSA-N

反应信息

• 作为反应物：
  描述：

  在 palladium dihydroxide 氢气 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 5.0h， 生成 (1R,3S,4R,6S,8R,9R,10S,12R,13S,22S,23S,24R,25R,27R)-10,12,25-triamino-9-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-23,24,27-trihydroxy-4-(hydroxymethyl)-2,5,7,14,26-pentaoxa-20-azatetracyclo[20.3.1.13,6.08,13]heptacosan-19-one
  参考文献：
  名称：

  6-Hydroxy to 6‴-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3′)-IIIa kinase

  摘要：

  Based on molecular modeling and available X-ray structure data on aminoglycosides complexed with a bacterial ribosomal surrogate or with a kinase, two analogues of paromomycin were prepared by tethering the 6-OH and the 6"'-NH2 group with a five-carbon bridge. Only one of two possible hydroxyl groups was phosphorylated by the kinase. The application of ring closure metathesis is presented for the first time to construct bridged macrocyclic analogues in the aminoglycoside series. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.014
• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 以15.3 mg的产率得到
  参考文献：
  名称：

  6-Hydroxy to 6‴-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3′)-IIIa kinase

  摘要：

  Based on molecular modeling and available X-ray structure data on aminoglycosides complexed with a bacterial ribosomal surrogate or with a kinase, two analogues of paromomycin were prepared by tethering the 6-OH and the 6"'-NH2 group with a five-carbon bridge. Only one of two possible hydroxyl groups was phosphorylated by the kinase. The application of ring closure metathesis is presented for the first time to construct bridged macrocyclic analogues in the aminoglycoside series. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.014