1-碘-4-(2-甲氧基乙氧基)苯 | 102293-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-碘-4-(2-甲氧基乙氧基)苯
• 英文名称: 1-Iodo-4-(2-methoxyethoxy)benzene
• 英文别名: 4-(2-methoxyethoxy)-iodobenzene
• CAS: 102293-99-2
• 化学式: C₉H₁₁IO₂
• mdl: MFCD14647006
• 分子量: 278.09
• InChiKey: SWYNRJGYKYTVFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-碘-4-(2-甲氧基乙氧基)苯 、 1-(decyloxy)-4-(2-(2-(2-(4-(decyloxy)phenyl)ethynyl)-4,5-diethylphenyl)ethynyl)benzene 在 copper(l) iodide 、 四(三苯基膦)钯 、 三乙胺 作用下， 以92%的产率得到1-(2-(4,5-bis(2-(4-(2-methoxyethoxy)phenyl)ethynyl)-2-(2-(4-(decyloxy)phenyl)ethynyl)phenyl)ethynyl)-4-(decyloxy)benzene
  参考文献：
  名称：

  矩形OPE两亲物的二维自组织成微晶薄片。

  摘要：

  纳米石墨状薄片是通过矩形OPE两亲物的自组装而获得的，该两亲物在外围装饰有极性和石蜡链。

  DOI：

  10.1039/b916418a
• 作为产物：
  描述：

  4-碘苯酚 、 2-溴乙基甲基醚 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 4.0h， 以46%的产率得到1-碘-4-(2-甲氧基乙氧基)苯
  参考文献：
  名称：

  Synthesis of Substituted [8]Cycloparaphenylenes by [2 + 2 + 2] Cycloaddition

  摘要：

  A new modular approach to the smallest substituted cycloparaphenylenes (CPPs) is presented. This versatile method permits access to substituted CPPs, choosing the substituent at a late stage of the synthesis. Variously substituted [8]CPPs have been synthesized, and their properties analyzed. The structural characteristics of substituted CPPs are close to those of unsubstituted CPPs. However, their optoelectronic behavior differs remarkably due to the larger torsion angle between the phenyl units.

  DOI：

  10.1021/ol500194s

文献信息

• Heterocyclic Carbamate Derivatives, Their Manufacture And Use As Pharmaceutical Agents
  申请人：Honold Konrad

  公开号：US20080009492A1

  公开（公告）日：2008-01-10

  Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式I的化合物，它们的药学上可接受的盐、对映体形式、二对映异构体和消旋体，上述化合物的制备，含有它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• [EN] SUBSTITUTED BENZENE COMPOUNDS<br/>[FR] COMPOSÉS DE BENZÈNE SUBSTITUÉS
  申请人：EPIZYME INC

  公开号：WO2015010049A1

  公开（公告）日：2015-01-22

  The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及取代苯化合物。本发明还涉及含有这些化合物的药物组合物以及通过向需要的受试者投予这些化合物和药物组合物来治疗癌症的方法。本发明还涉及利用这些化合物进行研究或其他非治疗目的的用途。
• [EN] NEW AZETIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS D'AZÉTIDINE, COMPOSITIONS PHARMACEUTIQUES CORRESPONDANTES ET LEURS UTILISATIONS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013098373A1

  公开（公告）日：2013-07-04

  The invention relates to new azetidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  这项发明涉及到新的式(I)的氮杂环丁烷衍生物，以及它们作为药物的用途，用于它们的治疗用途的方法，以及含有它们的药物组合物。
• Phenethanolamine compounds
  申请人：Glaxo Group Limited

  公开号：US04990505A1

  公开（公告）日：1991-02-05

  The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The compounds of formula (I) have a selective stimulant action at .beta..sub.2 -adrenoreceptors and are useful, in particular in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

  该发明提供了一般式(I)的化合物 ##STR1## 其中取代基在说明书中定义，并且其生理上可接受的盐和溶剂化合物。式(I)的化合物在β2-肾上腺素受体上具有选择性的兴奋作用，并且特别适用于治疗与可逆性气道阻塞相关的疾病，如哮喘和慢性支气管炎。
• ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Celgene Corporation

  公开号：US20200163948A1

  公开（公告）日：2020-05-28

  Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

  本文揭示了化学式I的化合物，用于治疗、预防或管理癌症。还揭示了治疗、预防或管理癌症的方法，例如治疗白血病，包括给予这些化合物。在某些实施例中，治疗方法包括与第二药物联合给药。此外，还揭示了包含这些化合物的药物组合物和单剂量形式。