2-Methyloctahydro-1H-4,7-methanoisoindole | 88391-81-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-Methyloctahydro-1H-4,7-methanoisoindole
• 英文别名: 4-methyl-4-azatricyclo[5.2.1.02,6]decane
• CAS: 88391-81-5
• 化学式: C₁₀H₁₇N
• 分子量: 151.25
• InChiKey: AUGCBWNTAFVEES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE<br/>[FR] INHIBITEURS DE SERINE PROTEASES, EN PARTICULIER LA NS3-NS4A PROTEASE DU HCV
  申请人：VERTEX PHARMACEUTICALS INCOPOR

  公开号：WO2005037860A2

  公开（公告）日：2005-04-28

  The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.