[4-(3-ethyl-2,4,4-trimethylcyclohexylmethyl)benzoyl]urea | 1609535-68-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [4-(3-ethyl-2,4,4-trimethylcyclohexylmethyl)benzoyl]urea
• CAS: 1609535-68-3
• 化学式: C₂₀H₃₀N₂O₂
• 分子量: 330.47
• InChiKey: HOSSYKWQYSINRO-UHFFFAOYSA-N

物化性质

• 熔点：
  160-165 °C
• 密度：
  1.026±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  (E)-[4-(3-ethyl-2,4,4-trimethylcyclohex-2-enylidenemethyl)benzoyl]urea 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 12.0h， 以82%的产率得到[4-(3-ethyl-2,4,4-trimethylcyclohexylmethyl)benzoyl]urea
  参考文献：
  名称：

  N-Carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide Enhances Staurosporine Cytotoxic Effects Likely Inhibiting the Protective Action of Magmas toward Cell Apoptosis

  摘要：

  We recently demonstrated that Magmas overexpression protects GH-secreting rat pitutitary adenoma cell lines from apoptosis by inhibiting cytochrome c release from mitochondria after treatment with staurosporine, strongly suggesting a role of Magmas in preventing apoptosis. The aim of this study was to produce a drug that, by inhibiting Tim16, may sensitize chemoresistant tumor cell to proapoptotic stimuli. We synthesized six compounds and challenged their sensitizing effects toward the proapoptotic effects of staurosporine in the TT cell line, derived from a human medullary thyroid carcinoma. We found that compound 5, devoid of the planarity in the aliphatic part of the lead 1, is not cytotoxic but enhances the proapoptotic effects of staurosporine by reducing MMP activation. Compound 5 may be useful for cancer treatment in association with chemotherapeutic drugs, possibly allowing a reduction of the chemotherapeutic agent effective dose.

  DOI：

  10.1021/jm5000535