3-{[(2-{[(2-mercaptoquinolin-3-yl)methylene]amino}phenyl)imino]methyl}quinoline-2-thiol | 1236988-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-{[(2-{[(2-mercaptoquinolin-3-yl)methylene]amino}phenyl)imino]methyl}quinoline-2-thiol
• 英文别名: MPQT；3-[[2-[(2-sulfanylidene-1H-quinolin-3-yl)methylideneamino]phenyl]iminomethyl]-1H-quinoline-2-thione
• CAS: 1236988-50-3
• 化学式: C₂₆H₁₈N₄S₂
• 分子量: 450.588
• InChiKey: HBSFZYXHYPQROF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-formyl-2-mercaptoquinoline 、 邻苯二胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以78%的产率得到3-{[(2-{[(2-mercaptoquinolin-3-yl)methylene]amino}phenyl)imino]methyl}quinoline-2-thiol
  参考文献：
  名称：

  Synthesis, Characterization, and DNA Binding Studies of S₂N₂ Donor Bis-Mercaptoquinoline Co(II) and Ni(II) Metal Complexes: A New Class of Antimicrobial Agent

  摘要：

  This article describes a convenient procedure for the synthesis of metal complexes of the type [ML] [CoMPQT](1), [NiMPQT](2) where M = Co(II), Ni(II) tetradentate (S2N2) Schiff-base using 3-[(2-[(2-mercaptoquinolin-3-yl)methylene]aminophenyl)imino]methyl quinoline-2-thiol ligand (MPQT)L. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, 1H NMR, mass, and electronic spectra. The mode of bonding and the geometry of the complexes have been confirmed on the basis of IR and UV-vis spectral findings and magnetic measurements. The binding property of the complexes with calf-thymus DNA was studied by absorption spectra, viscosity measurements, and thermal denaturation studies. The intrinsic binding constant (Kb) had the value 2.8 x 104 M-1 for 1 and 4.8 x 104 M-1 for 2, suggesting that complex 2 binds more strongly to CT-DNA than complex 1. The synthesized metal complexes were screened for antibacterial and antifungal activities. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500902845746