2-(cyclohex-1-en-1-yl)-1-(4-fluorobenzoyl)-3H-pyrrolo[2,3-c]quinolin-4(5H)-one | 1512759-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(cyclohex-1-en-1-yl)-1-(4-fluorobenzoyl)-3H-pyrrolo[2,3-c]quinolin-4(5H)-one
• 英文别名: 2-(Cyclohexen-1-yl)-1-(4-fluorobenzoyl)-3,5-dihydropyrrolo[2,3-c]quinolin-4-one；2-(cyclohexen-1-yl)-1-(4-fluorobenzoyl)-3,5-dihydropyrrolo[2,3-c]quinolin-4-one
• CAS: 1512759-27-1
• 化学式: C₂₄H₁₉FN₂O₂
• 分子量: 386.425
• InChiKey: VPMLJLBUEQBEOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (isocyanotosylmethylidene)cyclohexane 、 1,3-dihydro-3-[2-(4-fluorophenyl)-2-oxoethylidene]indol-2(1H)-one 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以85%的产率得到2-(cyclohex-1-en-1-yl)-1-(4-fluorobenzoyl)-3H-pyrrolo[2,3-c]quinolin-4(5H)-one
  参考文献：
  名称：

  Chemoselective synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives from 3-phenacylideneoxindoles and substituted tosylmethyl isocyanide (TosMIC)

  摘要：

  A simple and convenient synthetic approach to access of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives by the reaction of (Z)-3-(2-oxo-2-ethylidene)indolin-2-one derivatives 1 with functionalized TosMICs under basic conditions has been reported. The desired products were obtained in good to excellent yields (82-94%). The easy accessibility of the starting materials, simple and mild reaction conditions, short reaction time, and good to excellent chemical yields make this methodology highly efficient. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.10.084

文献信息

• Chemoselective synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives from 3-phenacylideneoxindoles and substituted tosylmethyl isocyanide (TosMIC)
  作者：Rong Wang、Shun-Yi Wang、Shun-Jun Ji

  DOI：10.1016/j.tet.2013.10.084

  日期：2013.12

  A simple and convenient synthetic approach to access of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives by the reaction of (Z)-3-(2-oxo-2-ethylidene)indolin-2-one derivatives 1 with functionalized TosMICs under basic conditions has been reported. The desired products were obtained in good to excellent yields (82-94%). The easy accessibility of the starting materials, simple and mild reaction conditions, short reaction time, and good to excellent chemical yields make this methodology highly efficient. (C) 2013 Elsevier Ltd. All rights reserved.