ethyl (Z)-3-amino-3-(3,5-dimethoxyphenyl)prop-2-enoate | 1456613-46-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl (Z)-3-amino-3-(3,5-dimethoxyphenyl)prop-2-enoate
• CAS: 1456613-46-9
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: HOFAVHWJKXRZPQ-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl (Z)-3-amino-3-(3,5-dimethoxyphenyl)prop-2-enoate 在 10-甲基吖啶高氯酸盐 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以46%的产率得到2,5-bis(3,5-dimethoxyphenyl)-3,4-bis(ethoxycarbonyl)pyrrole
  参考文献：
  名称：

  3-氨基-3-苯基-2-丙烯酸乙酯衍生物对高取代吡咯的新型光敏环化反应

  摘要：

  Irradiation of nitrogen-saturated acetonitrile solutions containing ethyl 3-amino-3-phenyl-2-propenoate derivatives with the (Z)-configuration [(Z)-1] and 10-methylacridinium perchlorate (MAP) at wavelengths longer than 340 nm afforded the corresponding pyrrole derivatives in good to high yields without exhibiting a profound effect related to the substituents. An analysis of the Stern-Volmer plots for the fluorescence quenching of MAP by (Z)-1 showed that this sensitizer fluorescence is efficiently quenched, and hence electron transfer is confirmed to be involved in the primary process of the MAP-sensitized cyclization reactions of 1.

  DOI：

  10.3987/com-13-12755
• 作为产物：
  描述：

  3,5-二甲氧基苯甲酰氯 在 氨 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 ethyl (Z)-3-amino-3-(3,5-dimethoxyphenyl)prop-2-enoate
  参考文献：
  名称：

  3-氨基-3-苯基-2-丙烯酸乙酯衍生物对高取代吡咯的新型光敏环化反应

  摘要：

  Irradiation of nitrogen-saturated acetonitrile solutions containing ethyl 3-amino-3-phenyl-2-propenoate derivatives with the (Z)-configuration [(Z)-1] and 10-methylacridinium perchlorate (MAP) at wavelengths longer than 340 nm afforded the corresponding pyrrole derivatives in good to high yields without exhibiting a profound effect related to the substituents. An analysis of the Stern-Volmer plots for the fluorescence quenching of MAP by (Z)-1 showed that this sensitizer fluorescence is efficiently quenched, and hence electron transfer is confirmed to be involved in the primary process of the MAP-sensitized cyclization reactions of 1.

  DOI：

  10.3987/com-13-12755

文献信息

• Novel Photosensitized Cyclization Reactions of Ethyl 3-Amino-3-phenyl-2-propenoate Derivatives to Highly Substituted Pyrroles
  作者：Tadamitsu Sakurai、Yohsuke Ishida、Yuhki Yoshida、Tetsutaro Igarashi

  DOI：10.3987/com-13-12755

  日期：——

  Irradiation of nitrogen-saturated acetonitrile solutions containing ethyl 3-amino-3-phenyl-2-propenoate derivatives with the (Z)-configuration [(Z)-1] and 10-methylacridinium perchlorate (MAP) at wavelengths longer than 340 nm afforded the corresponding pyrrole derivatives in good to high yields without exhibiting a profound effect related to the substituents. An analysis of the Stern-Volmer plots for the fluorescence quenching of MAP by (Z)-1 showed that this sensitizer fluorescence is efficiently quenched, and hence electron transfer is confirmed to be involved in the primary process of the MAP-sensitized cyclization reactions of 1.